Mogući antiaritmički učinak višestruko nezasićenih masnih kiselina

master's thesis

• Title (english): Possible antiarrhythmic effect of multiple unsaturated fatty acids
• Author: Mirna Pavlović
• Mentor: Martina Lovrić-Benčić (mentor)
• Committee member: Anton Šmalcelj (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Martina Lovrić-Benčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Višestruko nezasićene masne kiseline svakodnevan su sastojak naše prehrane. S godinama je uočen njihov blagotvoran učinak kod kardiovaskularnih bolesnika. Broj kardiovaskularnih bolesnika iz dana u dan sve više raste te višestruko nezasićene masne kiseline postaju uz svakodnevnu terapiju važna komponenta u liječenju tih bolesnika. Preventivni utjecaj višestruko nezasićenih masnih kiselina na aritmije područje je koje se danas intenzivno istražuje. Istraživanja na kulturi miocita pokazuju antiaritmički utjecaj omega-3 višestruko nezasićenih masnih kiselina. Slične rezultate pokazuju i mnoga istraživanja provedena na eksperimentalnim životinjama, pretežito na štakorima i psima. Mnoge kliničke studije rađene diljem svijeta pokazuju preventivno djelovanje omega-3 masnih kiselina. Usprkos tome, postoje randomizirane kliničke studije koje ne potvrđuju te rezultate. Kako bismo sami vidjeli kakav utjecaj omega-3 višestruko nezasićene masne kiseline imaju na pacijente koji se liječe na Klinici za bolesti srca i krvnih žila na KBC Rebro, napravljeno je istraživanje u kojem je sudjelovao 71 bolesnik. Rezultat istraživanja pokazao je značajno postoperativno smanjenje fibrilacija atrija kod bolesnika koji su uz klasičnu antiaritmičku terapiju uzimali i pripravak omega-3 višestruko nezasićenih masnih kiselina. Naše istraživanje pridonijelo je sveukupnom razumijevanju antiaritmičkog utjecanja omega-3 višestruko nezasićenih masnih kiselina.

Abstract (english)

Polyunsaturated fatty acids are the common ingredient of our diet. Over the years their beneficial effect in cardiovascular patients has been observed. The number of cardiovascular patients is growing every day and polyunsaturated fatty acids become an important component in the treatment of these patients in everyday therapy. The preventive effect of polyunsaturated fatty acids in the arrhythmia is an area that is now intensively investigated. Studies on myocyte cultures show antiarrhythmic effect of omega-3 polyunsaturated fatty acids. Many studies carried out on experimental animals, mainly in rats and dogs show similar results. Many clinical studies which are done around the world show a preventive effect of omega-3 fatty acids. Nevertheless, there are randomized clinical studies that do not confirm these results. The aim of our research with 71 patients was to see the effect of omega-3 polyunsaturated fatty acids on the patients treated at the Clinic for heart and blood vessel diseases at the University Hospital Rebro The result of the research showed a significant decrease of atrial fibrillation in patients with classical antiarrhythmic therapy who were taking the composition of omega-3 polyunsaturated fatty acids. Our research has contributed to the overall understanding of the antiarrhythmic influence of omega-3 polyunsaturated fatty acids.

• Keywords: višestruko nezasićene masne kiseline; omega-3; kardiovaskularni bolesnici; fibrilacija atrija
• Keywords (english): polyunsaturated fatty acids; omega-3; cardiovascular patients; atrial fibrillation
• Language: croatian
• URN:NBN: urn:nbn:hr:105:927221
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-06-28 10:32:10