Opstetrički rizici sindroma policističnih jajnika

master's thesis

• Title (english): Obstetric risks of polycystic ovary syndrome
• Author: Ivana Flisar
• Mentor: Trpimir Goluža (mentor)
• Committee member: Miro Kasum (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Trpimir Goluža (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Sindrom policističnih jajnika (PCOS) jedan je od najčešćih endokrinoloških poremećaja žena reproduktivne dobi. Iako ima raznoliku kliničku prezentaciju, glavne karakteristike PCOS-a su hiperandrogenizam, poremećaj ovulacije i policistični izgled jajnika. Navedene karakteristike ujedno predstavljaju i dijagnostičke kriterije. Prema nekim studijama, trudnoće u žena sa PCOS-om praćene su većim rizikom pojave brojnih opstetričkih rizika i komplikacija. Kliničke studije pokazuju kako je u trudnoća sa PCOS-om češća pojava ranog spontanog pobačaja, gestacijskog dijabetesa, preeklampsije i trudnoćom inducirane hipertenzije. Također, uočena je veća učestalost prijevremenog poroda i carskog reza u žena sa PCOS-om, perinatalne smrtnosti i prijema u neonatalne jedinice intenzivnog liječenja. Promjena životnog stila, smanjenje tjelesne mase, prestanak pušenja i fizička aktivnost pokazali su bitnu ulogu u smanjenju pojave opstetričkih rizika u trudnica sa PCOS-om. Osim toga, korištenje metformina u liječenju gestacijskog dijabetesa, sprječavanju ranih spontanih pobačaja i preeklampsije daje vrlo dobre rezultate prema nekim studijama. Unatoč tome, još uvijek ne postoje usuglašene smjernice vezane za sprječavanje i liječenje opstetričkih komplikacija.

Abstract (english)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age. Although it has diverse clinical presentation, main signs and symptoms of PCOS are as follows: excess androgen, chronic anovulations and polycystic morphology of the ovaries. These signs and symptoms also represent the core of diagnostic criteria. According to some studies, women with PCOS are at higher risk for pregnancy and delivery complications. Clinical research studies show that pregnant women with PCOS are more likely to have miscarriage in early pregnancy, gestational diabetes, preeclampsia and pregnancy induced hypertension. Also, there has been noted more common preterm birth, C – section, higher perinatal mortality rate and higher rate of neonatal intensive care unit admission in PCOS patients than in control women. Lifestyle changes, body weight reduction, quitting smoking and physical activity have shown significant role in reducing obstetric risks in pregnant women with PCOS. According to some studies the use of metformin has shown good therapeutic results in gestational diabetes treatment, preventing early pregnancy loss and preeclampsia. Nevertheless, there aren’t any standardized guidelines for preventing and treating obstetric complications in PCOS women.

• Keywords: PCOS; opstetričke komplikacije; rani spontani pobačaj; gestacijski dijabetes; preeklampsija; metformin
• Keywords (english): PCOS; obstetric complications; early pregnancy loss; gestational diabetes; preeclampsia; metformin
• Language: croatian
• URN:NBN: urn:nbn:hr:105:584419
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-10 13:25:45