Uzročno posljedična veza depresije i demencije

master's thesis

• Title (english): Causative association between despression and dementia
• Author: Tina Herljević
• Mentor: Ninoslav Mimica (mentor)
• Committee member: Neven Henigsberg (predsjednik povjerenstva)
• Committee member: Dražen Begić (član povjerenstva)
• Committee member: Ninoslav Mimica (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry

Abstract

Depresija je poremećaj raspoloženja koji se očituje sniženim raspoloženjem, gubitkom interesa i osjećajem krivnje i tuge koji negativno utječu na funkcioniranje oboljelog. Demencija ili kronični moždani sindrom obuhvaća različite kliničke entitete kojima je zajedničko da dovode do teškoća pamćenja i zaključivanja, promjene ličnosti i smanjene mogućnosti za obavljanje svakodnevnih aktivnosti. Prevalencija depresije i demencije je vrlo visoka u starijoj dobi te se često pojavljuju zajedno. Međutim, njihova povezanost još uvijek nije jednoznačno objašnjena te postoje mnoga različita tumačenja. Postoje dokazi da depresija u mlađoj dobi može biti rizični čimbenik za razvoj demencije kasnije u životu, a depresija koja se prvi puta javlja u starijoj dobi češće predstavlja prodrom demencije. Depresija i demencija dijele mnoge zajedničke rizične čimbenike poput slabijeg obrazovanja i niskog socioekonomskog statusa, histološki vidljivih promjena na mozgu i promjena na razini neurotransmitera, hormonalnih poremećaja, socijalne izolacije i općenitog nezadovoljstva vlastitim životom. Postoje dokazi da se depresija može javiti u ranoj fazi demencije kao reakcija na kognitivno propadanje, kao i da u oboljelih od depresije može doći do ranije pojave simptoma demencije. Uloga liječenja depresije na progresiju demencije još se uvijek intenzivno istražuje. Postoje dokazi o povoljnom djelovanju farmakološkog i nefarmakološkog liječenja depresije na usporenje progresije simptoma demencije, no prisutne su i značajne individualne razlike. Sa progresijom demencije, liječenje pokazuje sve manju učinkovitost i počinje se orijentirati na kontrolu simptoma i poboljšanje kvalitete života.

Abstract (english)

Depression is a mood disorder characterized by low mood, loss of interest and feelings of guilt and sadness that have a negative impact on human functioning. Dementia or chronic organic brain syndrome includes different clinical entities that present with memory loss, personality change and reduced ability to perform everyday activities. Prevalence of depression and dementia is very high in old age and they frequently coexist. However, their connection is still not fully understood and there are many different explanations. There is evidence of early-onset depression being a risk factor for developing dementia while late-onset depression is more often a prodrome of dementia. Depression and dementia share many common risk factors such as poor education and low socioeconomic status, histological brain changes, changes in neurotransmitter levels, hormonal changes, social isolation and general dissatisfaction in life. There is evidence of depression occurring in early phase of dementia as a reaction to cognitive decline. On the other side, people who already suffer from depression may exhibit symptoms of dementia earlier in life. The role of depression treatment on dementia progression is still being intensively researched. There is evidence of favourable impact of pharmacological and non-pharmacological depression treatment on slowing down the progression of dementia symptoms, but there are significant individual differences. As dementia progresses, treatment is less effective and starts to base on symptom control and improving the quality of life.

• Keywords: depresija; demencija; poremećaj raspoloženja; kronični moždani sindrom
• Keywords (english): depression; dementia; mood disorder; chronic organic brain syndrome
• Language: croatian
• URN:NBN: urn:nbn:hr:105:233277
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-13 06:49:30