Laboratorijska dijagnostika autoimunih bolesti kože

master's thesis

• Title (english): Laboratory diagnosis of autoimmune diseases of the skin
• Author: Andrea Domiter
• Mentor: Branka Marinović (mentor)
• Committee member: Zrinka Bukvić Mokos (predsjednik povjerenstva)
• Committee member: ALEKSANDRA BASTA-JUZBAŠIĆ (član povjerenstva)
• Committee member: Branka Marinović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Dermatology); Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Ovim diplomskim radom nastojat ću što jasnije prikazati najčešće autoimune bolesti kože i najznačajnije metode laboratorijske dijagnostike koje se koriste u postavljanju dijagnoze tih bolesti. Broj dostupnih dijagnostičkih metoda je širok, a dijagnostički postupak obuhvaća širok spektar postupaka od najjednostavnijih pa sve do onih složenijih i vremenski i financijski zahtjevnijih. Dijagnostički algoritam uvijek započinje osnovnim postupcima kao što su anamneza i klinički pregled na koje se potom nadovezuju opća laboratorijska dijagnostika i složeniji dijagnostički postupci čiji odabir ovisi o tome na što sumnjamo i što želimo dokazati ili isključiti. Počet ću sa opisom dostupnih dijagnostičkih mogućnosti usmjerenih na dokazivanje antitijela i ostalih bitnih parametara koji sudjeluju u etiopatogentskom procesu nastanka autoimunih bolesti, a u nastavku rada opisat ću najveće skupine autoimunih bolesti kože, točnije autoimune bulozne dermatoze i autoimune bolesti vezivnog tkiva. U sklopu opisa pojedine bolesti iz ovih skupina bolesti navest ću koji se točno dijagnostički postupak primjenjuje s ciljem postavljanja točne dijagnoze te ću kod svake bolesti ili skupine bolesti opisati nalaze pojedine dijagnostičke metode. Bolesti iz ove skupine često klinički nalikuju jednu na drugu te je iz tog razloga laboratorijska dijagnostika izuzetno važna te pomaže u razrješavanju često komplicirane diferencijalno dijagnostičke problematike.

Abstract (english)

In this thesis I will describe the most common autoimmune disease of the skin and the most important methods of laboratory diagnosis which are used in the diagnostic procedure of these diseases. The number of available diagnostic methods is wide, and the diagnostic procedure includes a wide range of procedures from the simplest up to those that are more complex in terms of time-demanding and financially aspects. Diagnostic algorithm always begins with basic procedures such as medical history and clinical examination. This, simple diagnostic procedures are further complemented by the general laboratory and more complex diagnostic procedures choice of which depends on what we suspect and we want to prove or exclude. I'll start with a description of the available diagnostic methods aim of which is to establish antibodies and other important parameters involved in the etiopathogenetic process of autoimmune diseases. Below I will describe the largest group of autoimmune skin diseases, specifically, group of autoimmune bullous dermatoses and a group of autoimmune connective tissue diseases. As part of the description of a particular disease in these groups of diseases I will describe the exact diagnostic procedure applied with the aim of setting up an accurate diagnosis. Diseases in this group often clinically resemble one on another, and for this reason the laboratory diagnosis is extremely important because it helps to solve the differential diagnosis problem which is often present in this diseases.

• Keywords: laboratorijska dijagnostika; bulozne autoimune dermatoze; autoimune bolesti vezivnog tkiva
• Keywords (english): laboratory diagnosis; autoimmune bullous dermatosis; autoimmune connective tissue disease
• Language: croatian
• URN:NBN: urn:nbn:hr:105:483244
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-09-23 11:40:00