Plasma levels of soluble TGF β receptor type III: no apparent promise as a marker in acute pancreatitis

Scientific paper - Original scientific paper

• Author: Grgur Salai
• Author: Marko Zelenika
• Author: Stela Hrkač
• Author: Vladimir Trkulja
• Author: Joško Bilandžić
• Author: Ivica Grgurević
• Author: Ruđer Novak
• Author: Lovorka Grgurević
• Author's institution: University of Zagreb; School of Medicine; (Department of Anatomy and Clinical Anatomy)
• Author's institution: University of Zagreb; School of Medicine; (Department of Pharmacology)
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Anatomy
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Pharmacology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Aim: To assess the potential of the soluble transforming growth factor β receptor type III (sTGFβrIII), a key regulator in TGFβ signaling, as a biomarker for diagnosis and stratification of patients with acute pancreatitis (AP).
------
Methods: In this small prospective pilot study, patients' (N=22) plasma samples were obtained at three time points: the first and fourth day of hospitalization and the day of hospital discharge. Healthy controls' plasma (N=25) was obtained at a single time point. Concentration of sTGFβrIII in plasma was determined by ELISA. Data were analyzed by fitting linear or linear mixed models.
-----
Results: Plasma sTGFβrIII levels at presentation (day 1) were similar in AP patients and healthy participants, irrespectively of the disease severity. sTGFβrIII levels in patients were constant during hospital stay.
-----
Conclusion: These observations do not support further evaluation of plasma sTGFβrIII levels in this setting, but do not exclude a potential biological role of TGFβ and membrane-bound TGFβrIII in AP pathophysiology.

• Keywords (english): Acute Disease; Biomarkers; Humans; Pancreatitis* / diagnosis; Pilot Projects; Prospective Studies
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 62, no. 3, pp. 264-269
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2021.62.264
• URN:NBN: urn:nbn:hr:105:377435
• Publication: 2021-06-30
• Document URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275940/
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-07-28 08:40:03