prikaz prve stranice dokumenta Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study
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Scientific paper - Original scientific paper
Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study
Bone Marrow Transplantation, 58 (2023), 11; 1209-1214. https://doi.org/10.1038/s41409-023-02077-2
Ruutu, Tapani; Peczynski, Christophe; Houhou, Mohamed; Polge, Emmanuelle; Mohty, Mohamad; Kröger, Nicolaus; Moiseev, Ivan; Penack, Olaf; Salooja, Nina; Schoemans, Hélène; Duarte, Rafael F.; Schroeder, Thomas; Passweg, Jakob; Wulf, Gerald G.; Ganser, Arnold; Sica, Simona; Arat, Mutlu; Salmenniemi, Urpu; Broers, Annoek E. C.; Bourhis, Jean Henri; Rambaldi, Alessandro; Maertens, Johan; Halaburda, Kazimierz; Zuckerman, Tsila; Labussière-Wallet, Hélène; Basak, Grzegorz; Koenecke, Christian; Perić, Zinaida More authors...

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Ruutu, T., Peczynski, C., Houhou, M., Polge, E., Mohty, M., Kröger, N. ... Perić, Z. (2023). Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study. Bone Marrow Transplantation, 58. (11), 1209-1214. doi: 10.1038/s41409-023-02077-2

Ruutu, Tapani, et al. "Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study." Bone Marrow Transplantation, vol. 58, no. 11, 2023, pp. 1209-1214. https://doi.org/10.1038/s41409-023-02077-2

Ruutu, Tapani, Christophe Peczynski, Mohamed Houhou, Emmanuelle Polge, Mohamad Mohty, Nicolaus Kröger, Ivan Moiseev, et al. "Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study." Bone Marrow Transplantation 58, no. 11 (2023): 1209-1214. https://doi.org/10.1038/s41409-023-02077-2

Ruutu, T., et al. (2023) 'Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study', Bone Marrow Transplantation, 58(11), pp. 1209-1214. doi: 10.1038/s41409-023-02077-2

Ruutu T, Peczynski C, Houhou M, Polge E, Mohty M, Kröger N, and sur.. Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study. Bone Marrow Transplantation [Internet]. 2023 August 12 [cited 2024 December 21];58(11):1209-1214. doi: 10.1038/s41409-023-02077-2

T. Ruutu, et al., "Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study", Bone Marrow Transplantation, vol. 58, no. 11, pp. 1209-1214, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:163794. [Accessed: 21 December 2024]

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Metadata
Title (english)Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study
AuthorTapani Ruutu
AuthorChristophe Peczynski
AuthorMohamed Houhou
AuthorEmmanuelle Polge
AuthorMohamad Mohty
AuthorNicolaus Kröger
AuthorIvan Moiseev
AuthorOlaf Penack
AuthorNina Salooja
AuthorHélène Schoemans
AuthorRafael F. Duarte
AuthorThomas Schroeder
AuthorJakob Passweg
AuthorGerald G. Wulf
AuthorArnold Ganser
AuthorSimona Sica
AuthorMutlu Arat
AuthorUrpu Salmenniemi
AuthorAnnoek E. C. Broers
AuthorJean Henri Bourhis
AuthorAlessandro Rambaldi
AuthorJohan Maertens
AuthorKazimierz Halaburda
AuthorTsila Zuckerman
AuthorHélène Labussière-Wallet
AuthorGrzegorz Basak
AuthorChristian Koenecke
AuthorZinaida Perić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All centers that had performed allogeneic HSCTs in adult patients within one defined year were invited to the study. Seventy-one centers participated with a total of 2886 allogeneic transplantations and 93 cases of VOD/SOS in 2018. The cumulative incidence of VOD/SOS at day 21 was 1.8% and at day 100 2.4%. Of 67 cases with detailed data, 52 were classical and 15 (22%) late onset (>day 21). According to the EBMT criteria, 65/67 patients had at least two VOD/SOS risk factors. The severity grades were: mild 0, moderate 3, severe 29, very severe 35. Fifty-four patients were treated with defibrotide. VOD/SOS resolved in 58% of the patients, 3/3 with moderate, 22/28 with severe, and 12/33 with very severe grade (p < 0.001). By day 100, 57% of the patients were alive; 3/3 with moderate, 22/29 with severe, and 13/35 with very severe VOD/SOS (p = 0.002). In conclusion, the incidence of VOD/SOS was low. Severe and very severe grades dominated. Very severe grade predicted poor outcome compared to severe grade further supporting the concept of early diagnosis and treatment to avoid a dismal outcome.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBone Marrow Transplantation
Numberingvol. 58, no. 11, pp. 1209-1214
p-ISSN0268-3369
e-ISSN1476-5365
DOIhttps://doi.org/10.1038/s41409-023-02077-2
URN:NBNurn:nbn:hr:105:163794
Publication2023-08-12
Document URLhttps://www.nature.com/articles/s41409-023-02077-2
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-08-26 08:13:18