prikaz prve stranice dokumenta Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial
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Scientific paper - Original scientific paper
Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial
Journal of Clinical Medicine, 12 (2023), 15; 4885. https://doi.org/10.3390/jcm12154885
Tomić Mahečić, Tina; Malojčić, Branko; Tonković, Dinko; Mažar, Mirabel; Baronica, Robert; Juren Meaški, Snježana; Crkvenac Gregorek, Andrea; Meier, Jens; Dünser, Martin W.

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Tomić Mahečić, T., Malojčić, B., Tonković, D., Mažar, M., Baronica, R., Juren Meaški, S. ... Dünser, M. W. (2023). Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial. Journal of Clinical Medicine, 12. (15). doi: 10.3390/jcm12154885

Tomić Mahečić, Tina, et al. "Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial." Journal of Clinical Medicine, vol. 12, no. 15, 2023. https://doi.org/10.3390/jcm12154885

Tomić Mahečić, Tina, Branko Malojčić, Dinko Tonković, Mirabel Mažar, Robert Baronica, Snježana Juren Meaški, Andrea Crkvenac Gregorek, Jens Meier and Martin W. Dünser. "Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial." Journal of Clinical Medicine 12, no. 15 (2023). https://doi.org/10.3390/jcm12154885

Tomić Mahečić, T., et al. (2023) 'Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial', Journal of Clinical Medicine, 12(15). doi: 10.3390/jcm12154885

Tomić Mahečić T, Malojčić B, Tonković D, Mažar M, Baronica R, Juren Meaški S, and sur.. Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial. Journal of Clinical Medicine [Internet]. 2023 July 25 [cited 2024 October 12];12(15). doi: 10.3390/jcm12154885

T. Tomić Mahečić, et al., "Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial", Journal of Clinical Medicine, vol. 12, no. 15, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:998267. [Accessed: 12 October 2024]

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Metadata
Title (english)Near-Infrared Spectroscopy-Guided, Individualized Arterial Blood Pressure Management for Carotid Endarterectomy under General Anesthesia: A Randomized, Controlled Trial
AuthorTina Tomić Mahečić
AuthorBranko Malojčić
AuthorDinko Tonković
AuthorMirabel Mažar
AuthorRobert Baronica
AuthorSnježana Juren Meaški
AuthorAndrea Crkvenac Gregorek
AuthorJens Meier
AuthorMartin W. Dünser
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Background: Differences in blood pressure can influence the risk of brain ischemia, perioperative complications, and postoperative neurocognitive function in patients undergoing carotid endarterectomy (CEA). Methods: In this single-center trial, patients scheduled for CEA under general anesthesia were randomized into an intervention group receiving near-infrared spectroscopy (NIRS)-guided blood pressure management during carotid cross-clamping and a control group receiving standard care. The primary endpoint was postoperative neurocognitive function assessed before surgery, on postoperative days 1 and 7, and eight weeks after surgery. Perioperative complications and cerebral autoregulatory capacity were secondary endpoints. Results: Systolic blood pressure (p < 0.001) and norepinephrine doses (89 (54–122) vs. 147 (116–242) µg; p < 0.001) during carotid cross-clamping were lower in the intervention group. No group differences in postoperative neurocognitive function were observed. The rate of perioperative complications was lower in the intervention group than in the control group (3.3 vs. 26.7%, p = 0.03). The breath-holding index did not differ between groups. Conclusions: Postoperative neurocognitive function was comparable between CEA patients undergoing general anesthesia in whom arterial blood pressure during carotid cross-clamping was guided using NIRS and subjects receiving standard care. NIRS-guided, individualized arterial blood pressure management resulted in less vasopressor exposition and a lower rate of perioperative complications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 12, no. 15, 4885
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm12154885
URN:NBNurn:nbn:hr:105:998267
Publication2023-07-25
Document URLhttps://www.mdpi.com/2077-0383/12/15/4885
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-09-02 08:29:07