Myocardial Infarction Susceptibility and the MTNR1B Polymorphisms

Scientific paper - Original scientific paper

• Author: Ivana Škrlec
• Author: Zrinka Biloglav
• Author: Jasminka Talapko
• Author: Snježana Džijan
• Author: Danijela Daus-Šebeđak
• Author: Vera Cesar
• Author's institution: University of Zagreb; School of Medicine; (Department of Medical Statistics, Epidemiology and Medical Informatics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Epidemiology

Abstract (english)

Melatonin is a circadian hormone with antioxidant properties that protects against myocardial ischemia-reperfusion injury. Genetic variations of the melatonin receptor 1B gene (MTNR1B) play an important role in the development of type 2 diabetes, a risk factor for cardiovascular diseases. Accordingly, MTNR1B polymorphisms are crucial in numerous disorders of the cardiovascular system. Therefore, the aim of the present study was to investigate a possible association of MTNR1B polymorphisms with chronotype and susceptibility to myocardial infarction. The present case-control study included 199 patients with myocardial infarction (MI) (57% men) and 198 control participants (52% men) without previous cardiovascular diseases who underwent genotyping for the MTNR1B polymorphisms rs10830963, rs1387153, and rs4753426 from peripheral blood samples. Chronotype was determined using the Morningness-Eveningness Questionnaire (MEQ). As estimated by the chi-square test, no significant association was found in the distribution of alleles and genotypes between myocardial infarction patients and controls. In addition, there was no association between MTNR1B polymorphisms and chronotype in MI patients. As some previous studies have shown, the present negative results do not exclude the role of the MTNR1B polymorphisms studied in the development of myocardial infarction. Rather, they may indicate that MTNR1B polymorphisms are a minor risk factor for myocardial infarction.

• Keywords (english): Case-Control Studies; Diabetes Mellitus, Type 2 / genetics; Female; Genetic Predisposition to Disease / genetics; Genotype; Humans; Male; Myocardial Infarction / genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptor, Melatonin, MT2 / genetics; Risk Factors
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Journal of Molecular Sciences
• Numbering: vol. 24, no. 14, 11444
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms241411444
• URN:NBN: urn:nbn:hr:105:817248
• Publication: 2023-07-14
• Project: Number: IP1-FDMZ-2022; Title (croatian): Povezanost varijabilnosti gena za receptor melatonina s osjetljivošću na infarkt miokarda; Title (english): The association of melatonin receptor gene variability with susceptibility to myocardial infarction; Leader: Ivana Škrlec; Jurisdiction: Croatia
• Document URL: https://www.mdpi.com/1422-0067/24/14/11444
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-09-05 07:07:37