Adherencija na lijekove u kardiovaskularnih bolesnika

master's thesis

• Title (english): Medication adherence in patients with cardiovascular disease
• Author: Petar Samardžić
• Mentor: Jure Samardžić (mentor)
• Committee member: Mislav Puljević (predsjednik povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Committee member: Jure Samardžić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Adherencija na lijekove definira se kao stupanj do kojeg pacijenti slijede propisanu terapiju. Dosadašnja istraživanja su pokazala da je slaba adherencija značajan problem u kardiovaskularnoj skrbi, što značajno utječe na zdravstvene ishode. Ovaj rad istražuje i uspoređuje adherenciju na tri grupe kardiovaskularnih lijekova – antihipertenzive, hipolipemike i hipoglikemike u odraslih bolesnika s poznatom koronarnom bolesti. Kohorta pacijenata koja je uzeta u istraživanje je dio uključenih pacijenata iz
Kliničkog bolničkog centra Zagreb u međunarodni EUROASPIRE IV i EUROASPIRE V registar koji su provođeni u različitim vremenskim intervalima (EUROASPIRE IV 2012. 2014.; EUROASPIRE V 2016.-2018.). Iz svakog registra je analizirano 50 pacijenata koji su prije najmanje šest mjeseci ili imali akutni koronarni sindrom ili im je elektivno postavljena intrakoronarna potpornica (stent) ili im je učinjeno aortokoronarno premoštenje. Analizirani su demografski podaci, suradljivost oko terapije, upitnici o kvaliteti života, depresiji i anksioznosti. Rezultati su pokazali kako je adherencija na terapiju bila u obje skupine odlična > 90% s time da je u EUROASPIRE V grupi bila značajnije i veća (99-100%). Nije bilo razlike u dobi, spolu, pušačkom statusu i tjelesnoj masi izmežu skupina bolesnika. Pacijenti u EUROASPIRE V grupi su imali bolju kvalitetu života, manje depresije i anksioznosti. Adherencija u sekundarnoj prevenciji kardiovaskularnih bolesti je dobra i preduvjet je za povoljnije ishode. Analiza većeg uzorka pacijenata je potrebna da bi rezultati imali značajnu snagu.

Abstract (english)

Adherence to medication is defined as the extent to which patients follow prescribed therapy. Previous research has shown that poor adherence is a significant problem in cardiovascular care, substantially affecting health outcomes. This study investigates and compares adherence to three groups of cardiovascular drugs — antihypertensives, lipid-lowering agents, and antidiabetic drugs in adult patients with known coronary artery disease. The patient cohort included in the study is part of the patients from the University Hospital Centre Zagreb enrolled in the international EUROASPIRE IV and EUROASPIRE V registries, conducted at different time periods (EUROASPIRE IV 2012-2014; EUROASPIRE V 2016-2018). From each registry, 50 patients were analyzed who, at least six months prior, had either experienced acute coronary syndrome or had undergone elective intracoronary stent placement or coronary artery bypass grafting. Demographic data, medication adherence, and questionnaires on quality of life, depression, and anxiety were analyzed. The results showed that adherence to therapy was excellent in both groups, >90%, with significantly higher adherence in the EUROASPIRE V group (99-100%). There were no differences in age, sex, smoking status, or body mass between the groups. Patients in the EUROASPIRE V group had a better quality of life and less depression and anxiety. Adherence in secondary prevention of cardiovascular diseases is good and a prerequisite for favorable outcomes. An analysis of a larger sample of patients is needed for the results to have higher significance.

• Keywords: adherencija; kardiovaskularne bolesti; kardiovaskularni lijekovi
• Keywords (english): adherence; cardiovascular diseases; cardiovascular drugs
• Language: croatian
• URN:NBN: urn:nbn:hr:105:010616
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-09 17:44:01