Značaj hiperbarične oksigenoterapije u liječenju oboljelih od sustavne skleroze

master's thesis

• Title (english): The significance of hyperbaric oxygenation therapy in patients with systemic sclerosis
• Author: Klara Svalina
• Mentor: Ana Gračanin Gudelj (mentor)
• Committee member: Marija Bakula (predsjednik povjerenstva)
• Committee member: Ivana Vuković Brinar (član povjerenstva)
• Committee member: Ana Gračanin Gudelj (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2024-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Sistemska skleroza (SSc) kronična je autoimuna bolest vezivnog tkiva koja zahvaća kožu, unutarnje organe i muskuloskeletni sustav. Jedna od prvih manifestacija bolesti može biti Raynaudov fenomen (RF) koji je prisutan u većine oboljelih. Učestala vazokonstrikcija uz strukturnu promjenu kapilara, uzrok je povećanom riziku razvoja digitalnih ulceracija i boli u perifernim zglobovima.
Cilj ovog istraživanja bio je utvrditi učinkovitost hiperbarične oksigenoterapije (HBOT) kao terapijske opcije za pacijente sa SSc i RF. Istraživanje je provedeno u Kliničkoj bolnici "Sveti Duh" i poliklinici za baromedicinu i medicinu rada "Oxy", podružnica Zagreb, a uključivalo je 29 ispitanika, od toga 3 muškarca (10%) i 26 žena (90%) prosječne dobi od 56±11 godina. Većina ispitanika imala je nespecificirani oblik SSc,18 (62%), limitirani oblik imalo je 7 (24%), a difuzni 4 (14%). Kao mjerilo učinkovitosti terapije koristio se vizualni analogni sustav (VAS) za određivanje boli u perifernim zglobovima i općeg umora prije i nakon odrađene terapije u barokomori. Dobivene su se vrijednosti usporedile te je dokazana statistički značajna razlika u VAS vrijednosti prije i nakon HBOT, p vrijednost <0,05. Dodatno je svaki ispitanik dobio na ispunjavanje upitnik o kvaliteti života SF-36 čiji su rezultati pokazali smanjenu kvalitetu života u svim kategorijama. Rezultati su pokazali značajno smanjenje boli u perifernim zglobovima i općeg umora nakon provedene HBOT, što ukazuje na potencijalnu korist ove terapije u poboljšanju kvalitete života oboljelih. Nije zamijećena značajna razlika u učinkovitosti i odgovoru na terapiju HBOT između mlađih i starijih pacijenata. Međutim, zbog ograničenog broja ispitanika, potrebna su daljnja istraživanja kako bi se potvrdili ovi rezultati.

Abstract (english)

Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects the skin, internal organs, and musculoskeletal system. It is common for Raynaud’s phenomenon (RP) to be the first manifestation of SSc and it is present in most patients. Frequent vasoconstriction along with structural changes in the capillaries, make these patients more susceptible to developing digital ulcers and pain in the peripheral joints.
The aim of this study was to evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) as a therapeutic option for patients with SSc and RP. The study was conducted at the Clinical Hospital "Sveti Duh" and the "Oxy" Polyclinic for hyperbaric and occupational medicine in Zagreb. The study included 29 participants, 3 men (10%) and 26 women (90%) with an average age of 56±11 years. Most participants had an unspecified form of SSc, 18 (62%), while 7 (24%) had a limited form, and 4 (14%) had a diffuse form of the disease. As a measure of therapy effectiveness, the visual analogue scale (VAS) was used to assess pain in peripheral joints and general fatigue before and after completed therapy in the hyperbaric chamber. The obtained values were compared, and there was a statistically significant difference in VAS values before and after HBOT was completed, with a p-value <0.05. Additionally, each participant was given the SF-36 quality of life questionnaire, which showed a reduced quality of life in all categories.
The results showed a significant reduction in peripheral joint pain and general fatigue after HBOT, indicating the potential benefit of this therapy in improving the quality of life for those affected. No significant difference was observed in the effectiveness and response to HBOT between younger and older patients. However, due to the limited number of participants, further research is needed to confirm these results.

• Keywords: sistemska skleroza; hiperbarična oksigenoterapija; liječenje sistemske skleroze; kvaliteta života
• Keywords (english): systemic sclerosis; hyperbaric oxygen therapy; treatment of systemic sclerosis; quality of life
• Language: croatian
• URN:NBN: urn:nbn:hr:105:543374
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-10 09:47:41