Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)

Scientific paper - Original scientific paper

• Author: Melissa Matz
• Author: Mikhail Valkov
• Author: Mario Šekerija
• Author: Sabine Luttman
• Author: Adele Caldarella
• Author: Michel P Coleman
• Author: Claudia Allemani
• Collaboration: CONCORD Working Group
• Author's institution: University of Zagreb; School of Medicine; (Department of Medical Statistics, Epidemiology and Medical Informatics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Epidemiology

Abstract (english)

Background: Esophageal cancer survival is poor worldwide, though there is some variation. Differences in the distribution of anatomical sub-site and morphological sub-type may help explain international differences in survival for all esophageal cancers combined. We estimated survival by anatomic sub-site and morphological sub-type to understand further the impact of topography and morphology on international comparisons of esophageal cancer survival.

Methods: We estimated age-standardized one-year and five-year net survival among adults (15-99 years) diagnosed with esophageal cancer in each of 60 participating countries to monitor survival trends by calendar period of diagnosis (2000-2004, 2005-2009, 2010-2014), sub-site, morphology, and sex.

Results: For adults diagnosed during 2010-2014, tumors in the lower third of the esophagus were the most common, followed by tumors of overlapping sub-site and sub-site not otherwise specified. The proportion of squamous cell carcinomas diagnosed during 2010-2014 was generally higher in Asian countries (50%-90%), while adenocarcinomas were more common in Europe, North America and Oceania (50%-60%). From 2000-2004 to 2010-2014, the proportion of squamous cell carcinoma generally decreased, and the proportion of adenocarcinoma increased. Over time, there were few improvements in age-standardized five-year survival for each sub-site. Age-standardized one-year survival was highest in Japan for both squamous cell carcinoma (67.7%) and adenocarcinoma (69.0%), ranging between 20%-60% in most other countries. Age-standardized five-year survival from squamous cell carcinoma and adenocarcinoma was similar for most countries included, around 15%-20% for adults diagnosed during 2010-2014, though international variation was wider for squamous cell carcinoma. In most countries, survival for both squamous cell carcinoma and adenocarcinoma increased by less than 5% between 2000-2004 and 2010-2014.

Conclusions: Esophageal cancer survival remains poor in many countries. The distributions of sub-site and morphological sub-type vary between countries, but these differences do not fully explain international variation in esophageal cancer survival.

• Keywords (english): Adenocarcinoma / epidemiology; Adenocarcinoma / pathology; Adult; Carcinoma, Squamous Cell / epidemiology; Esophageal Neoplasms / pathology; Humans; Infant
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Cancer Communications
• Numbering: vol. 43, no. 9, pp. 963-980
• p-ISSN: 2523-3548
• e-ISSN: 2523-3548
• DOI: https://doi.org/10.1002/cac2.12457
• URN:NBN: urn:nbn:hr:105:518891
• Publication: 2023-09
• Document URL: https://onlinelibrary.wiley.com/doi/10.1002/cac2.12457
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-09-24 11:11:24