prikaz prve stranice dokumenta Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements
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Scientific paper - Original scientific paper
Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements
Biomedicines, 12 (2024), 2; 323. https://doi.org/10.3390/biomedicines12020323
Barišić-Jaman, Mislav; Milošević, Marko; Skurla, Viktoria; Dohoczky, David; Stojić, Josip; Dinjar Kujundžić, Petra; Cigrovski Berković, Maja; Majić-Tengg, Ana; Matijaca, Ana; Lucijanić, Tomo; Kardum-Pejić, Mirjana; Pandžić Jakšić, Vlatka; Marušić, Srećko; Grgurević, Ivica

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Barišić Jaman, M., Milošević, M., Skurla, V., Dohoczky, D., Stojić, J., Dinjar Kujundžić, P. ... Grgurević, I. (2024). Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements. Biomedicines, 12. (2). doi: 10.3390/biomedicines12020323

Barišić Jaman, Mislav, et al. "Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements." Biomedicines, vol. 12, no. 2, 2024. https://doi.org/10.3390/biomedicines12020323

Barišić Jaman, Mislav, Marko Milošević, Viktoria Skurla, David Dohoczky, Josip Stojić, Petra Dinjar Kujundžić, Maja Cigrovski Berković, et al. "Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements." Biomedicines 12, no. 2 (2024). https://doi.org/10.3390/biomedicines12020323

Barišić Jaman, M., et al. (2024) 'Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements', Biomedicines, 12(2). doi: 10.3390/biomedicines12020323

Barišić Jaman M, Milošević M, Skurla V, Dohoczky D, Stojić J, Dinjar Kujundžić P, and sur.. Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements. Biomedicines [Internet]. 2024 January 30 [cited 2024 December 25];12(2). doi: 10.3390/biomedicines12020323

M. Barišić Jaman, et al., "Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements", Biomedicines, vol. 12, no. 2, January 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:663352. [Accessed: 25 December 2024]

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Metadata
Title (english)Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements
AuthorMislav Barišić-Jaman
AuthorMarko Milošević
AuthorViktoria Skurla
AuthorDavid Dohoczky
AuthorJosip Stojić
AuthorPetra Dinjar Kujundžić
AuthorMaja Cigrovski Berković
AuthorAna Majić-Tengg
AuthorAna Matijaca
AuthorTomo Lucijanić
AuthorMirjana Kardum-Pejić
AuthorVlatka Pandžić Jakšić
AuthorSrećko Marušić
AuthorIvica Grgurević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Patients with type 2 diabetes (T2D) are at risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the prevalence of compensated advanced chronic liver disease (cACLD) and steatosis in patients with T2D using the new non-invasive diagnostic methods of shear wave measurements (SWMs) and attenuation (ATT) measurements in comparison with those of vibration-controlled transient elastography (VCTE) and the controlled attenuation parameter (CAP), which served as the reference methods. Among 214 T2D patients, steatosis at any grade and cACLD were revealed in 134 (62.6%) and 19 (8.9%) patients, respectively. SWMs showed a high correlation with VCTE (Spearman’s ρ = 0.641), whereas SWMs produced lower (mean of −0.7 kPa) liver stiffness measurements (LSMs) overall. At a LSM of >11.0 kPa (Youden), SWMs had an AUROC of 0.951 that was used to diagnose cACLD (defined as a LSM of >15 kPa through VCTE) with 84.2% sensitivity and 96.4% specificity. The performance of ATT measurements in diagnosing liver steatosis at any grade (defined as the CAP of ≥274 dB/m) was suboptimal (AUROC of 0.744 at the ATT measurement cut-off of >0.63 dB/cm/MHz (Youden) with 59% sensitivity and 81.2% specificity). In conclusion, the prevalence of liver steatosis and previously unrecognized cACLD in patients with T2D is high and SWMs appear to be a reliable diagnostic method for this purpose, whereas further investigation is needed to optimize the diagnostic performance of ATT measurements.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 2, 323
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12020323
URN:NBNurn:nbn:hr:105:663352
Publication2024-01-30
Document URLhttps://www.mdpi.com/2227-9059/12/2/323
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-13 15:13:26