master's thesis
Etiology of encephalitis in children and adolescents

Ana Čučić (2016)
Sveučilište u Zagrebu
Medicinski fakultet
KATEDRA ZA INFEKTOLOGIJU
Metadata
TitleEtiologija encefalitisa u djece i adolescenata
AuthorAna Čučić
Mentor(s)Goran Tešović (thesis advisor)
Abstract
Encefalitis je upalni proces koji zahvaća moždani parenhim i posljedično dovodi do poremećaja moždane funkcije. U većini slučajeva upalni proces istodobno zahvaća i moždane ovojnice i tada govorimo o meningoencefalitisu. Prema etiologiji dijelimo ih na infektivne (primarne) i postinfektivne, u koje se ubrajaju i postvakcinalni, te autoimuni encefalitisi. Među infektivnim encefalitisima najčešći uzročnici su virusi i to herpes simplex virus (HSV) tip 1 i 2, nonpolio enterovirusi (NPEV), te arbovirusi (virusi koje prenose člankonožci). Iako je poznato više od 100 uzročnika akutnog encefalitisa više od 60% slučajeva ostane etiološki nedokazano. Autoimune encefalopatije etiološki se mogu podijeliti u paraneoplastične i ne paraneoplastične. Simptomi i znakovi autoimunog encefalitisa najčešće uključuju glavobolju, promjene u ponašanju, poremećaje pamćenja, poremećaje spavanja, epileptičke napadaje pa čak i poremećaje svijesti. Kod odraslih češće su autoimune encefalopatije paraneoplastićne etiologije, uzrokovane protutijelima na intracelularne antigene (Ma2, Hu) koje slabo reagiraju na imunoterapiju. Kod djece i adolescenata češći su encefalitisi uzrokovani protutijelima na površinske, odnosno sinaptičke antigene (NMDAR). U ovom radu prikazana je etiologija encefalitisa, te analiza podataka prikupljenih na 83 bolesnika koja su se liječila u Klinici za infektivne bolesti „Dr. Fran Mihaljević“ u periodu od 1.1.2011. do 31.12.2015. godine pod tom dijagnozom. Rezultati dobiveni ovim istraživanjem uspoređeni su s prethodnom studijom koja je analizirala etiologiju encefalitisa u djece i adolescenata u razdoblju 2000. – 2010. U odnosu na prethodno razdoblje razvidan je porast broja bolesnika s etiološki utvrđenom dijagnozom.
Keywordsetiology infections encephalitis autoimmune encephalitis
Parallel title (English)Etiology of encephalitis in children and adolescents
Committee MembersJosip Begovac (committee chairperson)
Marija Santini (committee member)
Goran Tešović (committee member)
GranterSveučilište u Zagrebu
Medicinski fakultet
Lower level organizational unitsKATEDRA ZA INFEKTOLOGIJU
PlaceZagreb
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Study programme typeuniversity
Study levelgraduate
Study programmeStudies in Nursing
Academic title abbreviationmag. med. techn.
Genremaster's thesis
Language Croatian
Defense date2016-09-29
Parallel abstract (English)
Encephalitis is a brain parenchyma inflammation leading to the impairment of brain function. In majority of cases, inflammation concurrently spreads to brain membranes, leading to meningoencephalitis. The encephalitis can be due to its etiology categorized into infectious (primary), post-infectious (which includes post-vaccinal), and autoimmune. Viral infections, primarily herpes simplex virus (HSV) 1 and 2, non-polio enteroviruses, and arboviruses (arthropod borne) are the most common causes of infectious encephalitis. Although more than 100 infectious agents can cause acute encephalitis, in only 60% of cases the underlying etiology is identified. Etiology of autoimmune encephalopathies can be divided into paraneoplastic and non-paraneoplastic. Symptoms and signs of autoimmune encephalitis commonly include headache, behavioral changes, memory and sleep disturbances, seizures, and impaired consciousness. In adults, the autoimmune encephalopathies are most commonly paraneoplastic in nature and respond poorly to the immunosuppressive therapy. In children and adolescents, autoimmune encephalopathies are more commonly caused by autoantibodies targeting surface or synapse antigens (NMDAR). This thesis reviews the encephalitis etiology and presents the data on 83 with encephalitis treated at the University Hospital for Infectious Diseases “Dr. Fran Mihaljević” from January 1, 2011 to December 31, 2015. Results were compared to previouus data obtained from study covering 11-years period (2000 – 2010). Significantly difference in the number of etiologycaly confirmed cases were found.
Parallel keywords (Croatian)etiologija infektivni encefalitis autoimuni encefalitis
Resource typetext
Access conditionOpen access
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:105:476255
CommitterLovela Machala Poplašen