prikaz prve stranice dokumenta Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization
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Scientific paper - Original scientific paper
Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization
Pathogens, 13 (2024), 5; 411. https://doi.org/10.3390/pathogens13050411
Bandić Pavlović, Daniela; Pospišil, Mladen; Nađ, Marina; Vrbanović Mijatović, Vilena; Luxner, Josefa; Zarfel, Gernot; Grisold, Andrea; Tonković, Dinko; Dobrić, Mirela; Bedenić, Branka

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Bandić Pavlović, D., Pospišil, M., Nađ, M., Vrbanović Mijatović, V., Luxner, J., Zarfel, G. ... Bedenić, B. (2024). Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization. Pathogens, 13. (5). doi: 10.3390/pathogens13050411

Bandić Pavlović, Daniela, et al. "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization." Pathogens, vol. 13, no. 5, 2024. https://doi.org/10.3390/pathogens13050411

Bandić Pavlović, Daniela, Mladen Pospišil, Marina Nađ, Vilena Vrbanović Mijatović, Josefa Luxner, Gernot Zarfel, Andrea Grisold, Dinko Tonković, Mirela Dobrić and Branka Bedenić. "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization." Pathogens 13, no. 5 (2024). https://doi.org/10.3390/pathogens13050411

Bandić Pavlović, D., et al. (2024) 'Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization', Pathogens, 13(5). doi: 10.3390/pathogens13050411

Bandić Pavlović D, Pospišil M, Nađ M, Vrbanović Mijatović V, Luxner J, Zarfel G, and sur.. Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization. Pathogens [Internet]. 2024 May 15 [cited 2025 March 21];13(5). doi: 10.3390/pathogens13050411

D. Bandić Pavlović, et al., "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization", Pathogens, vol. 13, no. 5, May 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:722434. [Accessed: 21 March 2025]

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Metadata
Title (english)Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization
AuthorDaniela Bandić Pavlović
AuthorMladen Pospišil
AuthorMarina Nađ
AuthorVilena Vrbanović Mijatović
AuthorJosefa Luxner
AuthorGernot Zarfel
AuthorAndrea Grisold
AuthorDinko Tonković
AuthorMirela Dobrić
AuthorBranka Bedenić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Multidrug-resistant (MDR) bacteria of the utmost importance are extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacterales (CRE), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus spp. (VRE). In this study, an evaluation of MDR bacteria in surgical intensive care units in a tertiary referral hospital was conducted. The study aimed to characterize β-lactamases and other resistance traits of Gram-negative bacteria isolated in surgical intensive care units (ICUs). Disk diffusion and the broth dilution method were used for antibiotic susceptibility testing, whereas ESBL screening was performed through a double disk synergy test and an inhibitor-based test with clavulanic acid. A total of 119 MDR bacterial isolates were analysed. ESBL production was observed in half of the Proteus mirabilis, 90% of the Klebsiella pneumoniae and all of the Enterobacter cloacae and Escherichia coli isolates. OXA-48 carbapenemase, carried by the L plasmid, was detected in 34 K. pneumoniae and one E. coli and Enterobacter cloacae complex isolates, whereas NDM occurred sporadically and was identified in three K. pneumoniae isolates. OXA-48 positive isolates coharboured ESBLs belonging to the CTX-M family in all but one isolate. OXA-23 carbapenemase was confirmed in all A. baumannii isolates. The findings of this study provide valuable insight of resistance determinants of Enterobacterales and A. baumannii which will enhance surveillance and intervention strategies that are necessary to curb the ever-growing carbapenem resistance rates.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePathogens
Numberingvol. 13, no. 5, 411
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens13050411
URN:NBNurn:nbn:hr:105:722434
Publication2024-05-15
Document URLhttps://www.mdpi.com/2076-0817/13/5/411
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-02-05 14:25:32