prikaz prve stranice dokumenta Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity
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Scientific paper - Original scientific paper
Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity
Journal of Clinical Medicine, 13 (2024), 9; 2472. https://doi.org/10.3390/jcm13092472
Svaguša, Tomo; Žarak, Marko; Šušnjar, Dubravka; Gjorgjievska, Savica; Varvodić, Josip; Slišković, Nikola; Šestan, Gloria; Kušurin, Marko; Prkačin, Ingrid; Rudež, Igor

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Svaguša, T., Žarak, M., Šušnjar, D., Gjorgjievska, S., Varvodić, J., Slišković, N. ... Rudež, I. (2024). Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity. Journal of Clinical Medicine, 13. (9). doi: 10.3390/jcm13092472

Svaguša, Tomo, et al. "Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity." Journal of Clinical Medicine, vol. 13, no. 9, 2024. https://doi.org/10.3390/jcm13092472

Svaguša, Tomo, Marko Žarak, Dubravka Šušnjar, Savica Gjorgjievska, Josip Varvodić, Nikola Slišković, Gloria Šestan, Marko Kušurin, Ingrid Prkačin and Igor Rudež. "Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity." Journal of Clinical Medicine 13, no. 9 (2024). https://doi.org/10.3390/jcm13092472

Svaguša, T., et al. (2024) 'Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity', Journal of Clinical Medicine, 13(9). doi: 10.3390/jcm13092472

Svaguša T, Žarak M, Šušnjar D, Gjorgjievska S, Varvodić J, Slišković N, and sur.. Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity. Journal of Clinical Medicine [Internet]. 2024 April 24 [cited 2025 March 22];13(9). doi: 10.3390/jcm13092472

T. Svaguša, et al., "Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity", Journal of Clinical Medicine, vol. 13, no. 9, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:135475. [Accessed: 22 March 2025]

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Metadata
Title (english)Low Level of First Morning Urine Cardiac Troponin I: A Specific Hallmark of Aortic Stenosis Severity
AuthorTomo Svaguša
AuthorMarko Žarak
AuthorDubravka Šušnjar
AuthorSavica Gjorgjievska
AuthorJosip Varvodić
AuthorNikola Slišković
AuthorGloria Šestan
AuthorMarko Kušurin
AuthorIngrid Prkačin
AuthorIgor Rudež
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Background: It has recently been shown that cardiac-specific troponin I concentrations in first morning urine samples can be measured with commercially available tests. Due to their accumulation in the first morning urine, scientific papers indicate a potential predictive value for cardiovascular diseases. Therefore, the aim of this study was to compare the concentration of cardiac troponin I in the first morning urine in patients with severe aortic stenosis and the healthy population. Patients and Methods: Blood and first morning urine samples were collected from 34 healthy individuals (17 female) at University Hospital Merkur and 25 patients with severe aortic stenosis (14 female) before surgical treatment at University Hospital Dubrava. Cardiac troponin I and T values were determined using high-sensitivity assays using commercially available Abbott and Roche tests. Results: Patients with severe aortic stenosis had significantly lower troponin I concentrations in the first morning urine samples (0.3 ng/L (0.1–0.6)) as compared to the healthy population (15.2 ng/L (8.4–19.9)) (p < 0.001). There was no statistically significant difference in troponin T concentrations between healthy individuals and patients with severe aortic stenosis. In parallel, both I and T plasma troponin concentrations were significantly higher in patients with severe aortic stenosis. Conclusions: In patients with severe aortic stenosis, cardiac troponin I values in the first morning urine are significantly lower than in healthy subjects.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 13, no. 9, 2472
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm13092472
URN:NBNurn:nbn:hr:105:135475
Publication2024-04-24
Document URLhttps://www.mdpi.com/2077-0383/13/9/2472
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-02-20 08:15:40