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Scientific paper - Review paper
The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity
Pharmaceuticals, 17 (2024), 4; 461. https://doi.org/10.3390/ph17040461
Sikirić, Predrag; Boban Blagaić, Alenka; Štrbe, Sanja; Beketić Orešković, Lidija; Orešković, Ivana; Sikirić, Sunčana; Starešinić, Mario; Sever, Marko; Kokot, Antonio; Jurjević, Ivana; Matek, Danijel; Ćorić, Luka; Krežić, Ivan; Tvrdeić, Ante; Luetić, Krešimir; Batelja Vuletić, Lovorka; Pavić, Predrag; Meštrović, Tomislav; Sjekavica, Ivica; Škrtić, Anita; Seiwerth, Sven More authors...

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Sikirić, P., Boban Blagaić, A., Štrbe, S., Beketić Orešković, L., Orešković, I., Sikirić, S. ... Seiwerth, S. (2024). The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity. Pharmaceuticals, 17. (4). doi: 10.3390/ph17040461

Sikirić, Predrag, et al. "The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity." Pharmaceuticals, vol. 17, no. 4, 2024. https://doi.org/10.3390/ph17040461

Sikirić, Predrag, Alenka Boban Blagaić, Sanja Štrbe, Lidija Beketić Orešković, Ivana Orešković, Sunčana Sikirić, Mario Starešinić, et al. "The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity." Pharmaceuticals 17, no. 4 (2024). https://doi.org/10.3390/ph17040461

Sikirić, P., et al. (2024) 'The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity', Pharmaceuticals, 17(4). doi: 10.3390/ph17040461

Sikirić P, Boban Blagaić A, Štrbe S, Beketić Orešković L, Orešković I, Sikirić S, and sur.. The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity. Pharmaceuticals [Internet]. 2024 April 03 [cited 2025 April 16];17(4). doi: 10.3390/ph17040461

P. Sikirić, et al., "The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity", Pharmaceuticals, vol. 17, no. 4, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:802639. [Accessed: 16 April 2025]

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Metadata
Title (english)The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity
AuthorPredrag Sikirić
AuthorAlenka Boban Blagaić
AuthorSanja Štrbe
MBZ: 319335
AuthorLidija Beketić Orešković
AuthorIvana Orešković
AuthorSunčana Sikirić
AuthorMario Starešinić
AuthorMarko Sever
AuthorAntonio Kokot
AuthorIvana Jurjević
AuthorDanijel Matek
AuthorLuka Ćorić
AuthorIvan Krežić
AuthorAnte Tvrdeić
AuthorKrešimir Luetić
AuthorLovorka Batelja Vuletić
AuthorPredrag Pavić
AuthorTomislav Meštrović
AuthorIvica Sjekavica
AuthorAnita Škrtić
AuthorSven Seiwerth
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Surgery)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Radiology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Radiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
We highlight the particular aspects of the stable gastric pentadecapeptide BPC 157 pleiotropic beneficial activity (not destroyed in human gastric juice, native and stable in human gastric juice, as a cytoprotection mediator holds a response specifically related to preventing or recovering damage as such) and its possible relations with neurotransmitter activity. We attempt to resolve the shortage of the pleiotropic beneficial effects of BPC 157, given the general standard neurotransmitter... More criteria, in classic terms. We substitute the lack of direct conclusive evidence (i.e., production within the neuron or present in it as a precursor molecule, released eliciting a response on the receptor on the target cells on neurons and being removed from the site of action once its signaling role is complete). This can be a network of interconnected evidence, previously envisaged in the implementation of the cytoprotection effects, consistent beneficial particular evidence that BPC 157 therapy counteracts dopamine, serotonin, glutamate, GABA, adrenalin/noradrenalin, acetylcholine, and NO-system disturbances. This specifically includes counteraction of those disturbances related to their receptors, both blockade and over-activity, destruction, depletion, tolerance, sensitization, and channel disturbances counteraction. Likewise, BPC 157 activates particular receptors (i.e., VGEF and growth hormone). Furthermore, close BPC 157/NO-system relations with the gasotransmitters crossing the cell membrane and acting directly on molecules inside the cell may envisage particular interactions with receptors on the plasma membrane of their target cells. Finally, there is nerve-muscle relation in various muscle disturbance counteractions, and nerve-nerve relation in various encephalopathies counteraction, which is also exemplified specifically by the BPC 157 therapy application. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 17, no. 4, 461
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph17040461
URN:NBNurn:nbn:hr:105:802639
Publication2024-04-03
Document URLhttps://www.mdpi.com/1424-8247/17/4/461
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-02-20 09:30:55
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