Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study

Scientific paper - Original scientific paper

• Author: Vesna Sokol Karadjole
• Author: Antonio D’Amato
• Author: Milan Milošević
• Author: Mislav Herman
• Author: Mislav Mikuš
• Author: Antonio Simone Laganà
• Author: Vito Chiantera
• Author: Andrea Etrusco
• Author's institution: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics)
• Author's institution: University of Zagreb; School of Medicine; (Department of Environmental and Occupational Health)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Occupational and Sports Medicine

Abstract (english)

Background: Despite pregnancy’s hypercoagulable state, the correlation between inherited thrombophilia and thrombotic adverse pregnancy outcomes remains uncertain. The objective of this study was to determine the prevalence of inherited thrombophilic polymorphisms among asymptomatic pregnant individuals and to examine their potential correlation with adverse perinatal outcomes.
Methods: in this single-center prospective study, 105 healthy pregnant women were included. Genotyping was conducted... More for factor V Leiden (FVL), prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, and plasminogen activator inhibitor-1 (PAI-1), alongside the assessment of protein C (PC), protein S (PS), and antithrombin (AT) levels. The study analyzed the association between inherited thrombophilic polymorphisms and pregnancy complications linked to placental insufficiency, such as gestational hypertension (GH), preeclampsia (PE), intrauterine death (IUD), fetal growth restriction (FGR), and placental abruption. Results: The prevalence of identifiable thrombophilic polymorphism mutations was 61.9% (95% confidence interval—CI 52.4–70.8%), with the most common single mutation being PAI-1 4G/5G (12/105, 11.4%, 95% CI 6.4–18.5). The most frequent combined mutation was heterozygosity for MTHFR C677T and PAI-1 (12/105, 11.4%, 95% CI 6.4–18.5). Notably, no FVL homozygous carriers or single homozygous and heterozygous carriers for prothrombin polymorphisms were found. Additionally, no deficiencies in PC and AT were detected among participants. Except for homozygosity for PAI-1, none of the studied polymorphisms demonstrated a significant association with pregnancy complications linked to placental insufficiency.
Conclusions: The asymptomatic carriers of inherited thrombophilic polymorphisms do not have an increased risk of adverse perinatal outcomes. Less

• Keywords (english): healthy antenatal population; inherited thrombophilia; perinatal outcome
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Journal of Personalized Medicine
• Numbering: vol. 14, no. 4, 433
• e-ISSN: 2075-4426
• DOI: https://doi.org/10.3390/jpm14040433
• URN:NBN: urn:nbn:hr:105:207762
• Publication: 2024-04-19
• Document URL: https://www.mdpi.com/2075-4426/14/4/433
• Type of resource: Text
• Access conditions: Open access
• Created on: 2025-03-03 09:33:10