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Scientific paper - Review paper
Glioma Stem Cells—Features for New Therapy Design
Cancers, 16 (2024), 8; 1557. https://doi.org/10.3390/cancers16081557
Pećina-Šlaus, Nives; Hrašćan, Reno

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Pećina Šlaus, N. & Hrašćan, R. (2024). Glioma Stem Cells—Features for New Therapy Design. Cancers, 16. (8). doi: 10.3390/cancers16081557

Pećina Šlaus, Nives and Reno Hrašćan. "Glioma Stem Cells—Features for New Therapy Design." Cancers, vol. 16, no. 8, 2024. https://doi.org/10.3390/cancers16081557

Pećina Šlaus, Nives and Reno Hrašćan. "Glioma Stem Cells—Features for New Therapy Design." Cancers 16, no. 8 (2024). https://doi.org/10.3390/cancers16081557

Pećina Šlaus, N. and Hrašćan, R. (2024) 'Glioma Stem Cells—Features for New Therapy Design', Cancers, 16(8). doi: 10.3390/cancers16081557

Pećina Šlaus N, Hrašćan R. Glioma Stem Cells—Features for New Therapy Design. Cancers [Internet]. 2024 April 19 [cited 2025 March 14];16(8). doi: 10.3390/cancers16081557

N. Pećina Šlaus and R. Hrašćan, "Glioma Stem Cells—Features for New Therapy Design", Cancers, vol. 16, no. 8, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:689381. [Accessed: 14 March 2025]

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Metadata
Title (english)Glioma Stem Cells—Features for New Therapy Design
AuthorNives Pećina-Šlaus
AuthorReno Hrašćan
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cells that behave like stem cells and are known as glioma cancer stem cells (GCSCs). They are responsible for tumor plasticity and are influenced by genetic drivers. Additionally, GCSCs also display greater migratory abilities. A great effort is under way in order to find ways to eliminate or neutralize GCSCs. Many different treatment strategies are currently being explored, including modulation of the tumor microenvironment, posttranscriptional regulation, epigenetic modulation and immunotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCancers
Numberingvol. 16, no. 8, 1557
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers16081557
URN:NBNurn:nbn:hr:105:689381
Publication2024-04-19
Document URLhttps://www.mdpi.com/2072-6694/16/8/1557
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-03 10:04:55