prikaz prve stranice dokumenta Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
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Scientific paper - Original scientific paper
Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
Biomedicines, 12 (2024), 4; 750. https://doi.org/10.3390/biomedicines12040750
Sršen, Saša; Held, Martina; Šestan, Mario; Kifer, Nastasia; Kozmar, Ana; Šupe Domić, Daniela; Benzon, Benjamin; Gagro, Alenka; Frković, Marijan; Jelušić, Marija

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Sršen, S., Held, M., Šestan, M., Kifer, N., Kozmar, A., Šupe Domić, D. ... Jelušić, M. (2024). Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis. Biomedicines, 12. (4). doi: 10.3390/biomedicines12040750

Sršen, Saša, et al. "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis." Biomedicines, vol. 12, no. 4, 2024. https://doi.org/10.3390/biomedicines12040750

Sršen, Saša, Martina Held, Mario Šestan, Nastasia Kifer, Ana Kozmar, Daniela Šupe Domić, Benjamin Benzon, Alenka Gagro, Marijan Frković and Marija Jelušić. "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis." Biomedicines 12, no. 4 (2024). https://doi.org/10.3390/biomedicines12040750

Sršen, S., et al. (2024) 'Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis', Biomedicines, 12(4). doi: 10.3390/biomedicines12040750

Sršen S, Held M, Šestan M, Kifer N, Kozmar A, Šupe Domić D, and sur.. Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis. Biomedicines [Internet]. 2024 March 28 [cited 2025 March 03];12(4). doi: 10.3390/biomedicines12040750

S. Sršen, et al., "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis", Biomedicines, vol. 12, no. 4, March 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:419888. [Accessed: 03 March 2025]

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Metadata
Title (english)Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
AuthorSaša Sršen
AuthorMartina Held
AuthorMario Šestan
AuthorNastasia Kifer
AuthorAna Kozmar
AuthorDaniela Šupe Domić
AuthorBenjamin Benzon
AuthorAlenka Gagro
AuthorMarijan Frković
AuthorMarija Jelušić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (english)
S100A8/A9 protein is a well-known marker of disease activity or severity in many autoimmune and autoinflammatory diseases, but there have not been many studies about the role of S100A8/A9 in IgA vasculitis (IgAV). The aim of our study was to evaluate S100A8/A9 as a possible biomarker of activity in IgAV. We measured the serum levels of S100A8/A9 in pediatric patients with IgA vasculitis at the onset of the disease, after three months, and after six months. We compared these levels between patients with active disease, remission, and a control group, and assessed their correlation with disease activity and other markers of inflammation. Patients with active disease had significantly higher levels of serum S100A8/A9 (median ± SD) than those in the control group at the beginning of the disease (5740 ± 3157 ng/mL vs. 1447 ± 858.3 ng/mL; p < 0.0001), but also three months and six months after disease onset (p < 0.001). There was a positive correlation between S100A8/A9 serum levels and disease activity (p = 0.0003). Patients with active disease had significantly higher levels of S100A8/A9 than those in remission three months after disease onset (p = 0.0260). There was a correlation between S100A8/A9 and C-reactive protein, the C3 component of complement, ferritin, and fibrinogen. Serum levels of S100A8/A9 were also higher in patients with greater skin areas covered with rash. We demonstrated that serum levels of S100A8/A9 correlated well with disease activity and other biomarkers of inflammation in children with IgAV. According to our results, serum S100A8/A9 may be a good indicator of active disease in IgAV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 12, no. 4, 750
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12040750
URN:NBNurn:nbn:hr:105:419888
Publication2024-03-28
Document URLhttps://www.mdpi.com/2227-9059/12/4/750
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-03 11:40:12