prikaz prve stranice dokumenta Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
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Scientific paper - Original scientific paper
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
eLife, 13 (2024); e84173. https://doi.org/10.7554/eLife.84173
Moujaes, Flora; Ji, Jie Lisa; Rahmati, Masih; Burt, Joshua B; Schleifer, Charles; Adkinson, Brendan D; Savić, Aleksandar; Santamauro, Nicole; Tamayo, Zailyn; Diehl, Caroline; Kolobaric, Antonija; Flynn, Morgan; Rieser, Nathalie; Fonteneau, Clara; Camarro, Terry; Xu, Junqian; Cho, Youngsun; Repovs, Grega; Fineberg, Sarah K; Morgan, Peter T; Seifritz, Erich; Vollenweider, Franz X; Krystal, John H; Murray, John D; Preller, Katrin H; Anticevic, Alan More authors...

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Moujaes, F., Ji, J. L., Rahmati, M., Burt, J. B., Schleifer, C., Adkinson, B. D. ... Anticevic, A. (2024). Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. eLife, 13.. doi: 10.7554/eLife.84173

Moujaes, Flora, et al. "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures." eLife, vol. 13, 2024. https://doi.org/10.7554/eLife.84173

Moujaes, Flora, Jie Lisa Ji, Masih Rahmati, Joshua B Burt, Charles Schleifer, Brendan D Adkinson, Aleksandar Savić, et al. "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures." eLife 13 (2024). https://doi.org/10.7554/eLife.84173

Moujaes, F., et al. (2024) 'Ketamine induces multiple individually distinct whole-brain functional connectivity signatures', eLife, 13. doi: 10.7554/eLife.84173

Moujaes F, Ji JL, Rahmati M, Burt JB, Schleifer C, Adkinson BD, and sur.. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. eLife [Internet]. 2024 April 17 [cited 2025 April 25];13. doi: 10.7554/eLife.84173

F. Moujaes, et al., "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures", eLife, vol. 13, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:117979. [Accessed: 25 April 2025]

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Metadata
Title (english)Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
AuthorFlora Moujaes
AuthorJie Lisa Ji
AuthorMasih Rahmati
AuthorJoshua B Burt
AuthorCharles Schleifer
AuthorBrendan D Adkinson
AuthorAleksandar Savić
AuthorNicole Santamauro
AuthorZailyn Tamayo
AuthorCaroline Diehl
AuthorAntonija Kolobaric
AuthorMorgan Flynn
AuthorNathalie Rieser
AuthorClara Fonteneau
AuthorTerry Camarro
AuthorJunqian Xu
AuthorYoungsun Cho
AuthorGrega Repovs
AuthorSarah K Fineberg
AuthorPeter T Morgan
AuthorErich Seifritz
AuthorFranz X Vollenweider
AuthorJohn H Krystal
AuthorJohn D Murray
AuthorKatrin H Preller
AuthorAlan Anticevic
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects. Methods: We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition. 40 healthy participants received acute ketamine (initial bolus 0.23 mg/kg, continuous infusion 0.58 mg/kg/hr). We quantified resting-state functional connectivity via data-driven global brain connectivity and related it to individual ketamine-induced symptom variation and cortical gene expression targets. Results: We found that: (i) both the neural and behavioral effects of acute ketamine are multi-dimensional, reflecting robust inter-individual variability; (ii) ketamine's data-driven principal neural gradient effect matched somatostatin (SST) and parvalbumin (PVALB) cortical gene expression patterns in humans, while the mean effect did not; and (iii) behavioral data-driven individual symptom variation mapped onto distinct neural gradients of ketamine, which were resolvable at the single-subject level. Conclusions: These results highlight the importance of considering individual behavioral and neural variation in response to ketamine. They also have implications for the development of individually precise pharmacological biomarkers for treatment selection in psychiatry.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleeLife
Numberingvol. 13, e84173
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.84173
URN:NBNurn:nbn:hr:105:117979
Publication2024-04-17
Document URLhttps://elifesciences.org/articles/84173
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-06 10:06:20