prikaz prve stranice dokumenta Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
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Scientific paper - Original scientific paper
Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
Cancers, 16 (2024), 16; 2916. https://doi.org/10.3390/cancers16162916
Salar, Anamarija; Vuković Đerfi, Kristina; Pačić, Arijana; Škrtić, Anita; Čačev, Tamara; Kapitanović, Sanja

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Salar, A., Vuković Đerfi, K., Pačić, A., Škrtić, A., Čačev, T. & Kapitanović, S. (2024). Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer. Cancers, 16. (16). doi: 10.3390/cancers16162916

Salar, Anamarija, et al. "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer." Cancers, vol. 16, no. 16, 2024. https://doi.org/10.3390/cancers16162916

Salar, Anamarija, Kristina Vuković Đerfi, Arijana Pačić, Anita Škrtić, Tamara Čačev and Sanja Kapitanović. "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer." Cancers 16, no. 16 (2024). https://doi.org/10.3390/cancers16162916

Salar, A., et al. (2024) 'Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer', Cancers, 16(16). doi: 10.3390/cancers16162916

Salar A, Vuković Đerfi K, Pačić A, Škrtić A, Čačev T, Kapitanović S. Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer. Cancers [Internet]. 2024 August 22 [cited 2025 April 24];16(16). doi: 10.3390/cancers16162916

A. Salar, K. Vuković Đerfi, A. Pačić, A. Škrtić, T. Čačev and S. Kapitanović, "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer", Cancers, vol. 16, no. 16, August 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:290047. [Accessed: 24 April 2025]

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Metadata
Title (english)Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
AuthorAnamarija Salar
AuthorKristina Vuković Đerfi
AuthorArijana Pačić
AuthorAnita Škrtić
AuthorTamara Čačev
AuthorSanja Kapitanović
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Microsatellite instability (MSI) has been recognized as an important factor in colorectal cancer (CRC). It arises due to deficient mismatch repair (MMR), mostly attributed to MLH1 and MSH2 loss of function leading to a global MMR defect affecting mononucleotide and longer microsatellite loci. Recently, microsatellite instability at tetranucleotide loci, independent of the global MMR defect context, has been suggested to represent a distinct entity with possibly different consequences for tumorigenesis. It arises as a result of an isolated MSH3 loss of function due to its translocation from the nucleus to the cytoplasm under the influence of interleukin-6 (IL-6). In this study the influence of MSH3 and IL-6 signaling pathway polymorphisms (MSH3 exon 1, MSH3+3133A/G, IL-6-174G/C, IL-6R+48892A/C, and gp130+148G/C) on the occurrence of different types of microsatellite instability in sporadic CRC was examined by PCR–RFLP and real-time PCR SNP analyses. A significant difference in distribution of gp130+148G/C genotypes (p = 0.037) and alleles (p = 0.031) was observed in CRC patients with the C allele being less common in tumors with di- and tetranucleotide instability (isolated MSH3 loss of function) compared to tumors without microsatellite instability. A functional polymorphism in gp130 might modulate the IL-6 signaling pathway, directing it toward the occurrence of microsatellite instability corresponding to the IL-6-mediated MSH3 loss of function.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCancers
Numberingvol. 16, no. 16, 2916
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers16162916
URN:NBNurn:nbn:hr:105:290047
Publication2024-08-22
ProjectNumber: HRZZ-IP-2016-06-1430
Title (croatian): Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva
Title (english): Microsatellite instability (MSI and EMAST) in molecular profiling of sporadic colon cancers
Acronym: MSIandEMASTinCRC
Jurisdiction: Croatia
Funding stream: Research Projects
Document URLhttps://www.mdpi.com/2072-6694/16/16/2916
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-03-25 12:44:55