Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus

Scientific paper - Original scientific paper

• Author: Jelena Košćak Lukač
• Author: Koraljka Bačić Baronica
• Author: Alan Šućur
• Author: Josip Sremec
• Author: Sanja Tomasović
• Author: Robert Baronica
• Author: Tomislav Kelava
• Author: Danka Grčević
• Author: Nataša Kovačić
• Author's institution: University of Zagreb; School of Medicine; (Croatian Institiute for Brain Research)
• Author's institution: University of Zagreb; School of Medicine; (Department of Anatomy and Clinical Anatomy)
• Author's institution: University of Zagreb; School of Medicine; (Department of Physiology and Immunology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Human Physiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Anatomy

Abstract (english)

Epstein–Barr virus (EBV) infection and various chemokines, including CCL20, CXCL8 and CXCL10 are considered to participate in the pathogenesis of multiple sclerosis (MS), and several studies point to a direct regulatory effect of EBV on the expression of these chemokines. In our study we hypothesized that serum concentrations of CCL20, CXCL8 and CXCL0 are induced in patients with relapsing-remitting MS (RRMS) in comparison to healthy individuals, and that they are associated with EBV infection. Serum concentrations of CXCL8 and CXCL10 were lower in RRMS patients in relapse in comparison to healthy controls. Although potential effects of corticosteroid therapy introduced in a subgroup of RRMS patients prior to sampling were excluded by subgroup comparison, this possibility has to be considered while interpreting the results. We found an inverse association between serum concentrations of CXCL8 and anti-Epstein–Barr Virus Nuclear Antigen (EBNA) IgG and decreased expression of CXCL8 in peripheral blood mononuclear cells (PBMC) in relapse compared to remission. Lower serum concentrations of CXCL8 and CXCL10 in RRMS patients and decreased peripheral production of CXCL8 in relapse may indicate compensatory anti-inflammatory counter-regulation in MS.

• Keywords (english): Adult; Antibodies, Viral / blood; Antibodies, Viral / immunology; Case-Control Studies; Chemokine CCL20 / blood; Chemokine CXCL10 / blood; Epstein-Barr Virus Infections / blood; Epstein-Barr Virus Infections / immunology; Epstein-Barr Virus Infections / virology; Female; Herpesvirus 4, Human / immunology; Humans; Interleukin-8 / blood; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / metabolism; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting / blood; Multiple Sclerosis, Relapsing-Remitting / drug therapy; Multiple Sclerosis, Relapsing-Remitting / immunology; Multiple Sclerosis, Relapsing-Remitting / virology
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Journal of Molecular Sciences
• Numbering: vol. 25, no. 15, 8064
• e-ISSN: 1422-0067
• DOI: https://doi.org/10.3390/ijms25158064
• URN:NBN: urn:nbn:hr:105:711259
• Publication: 2024-07-24
• Project: Number: UIP-2017-05-1965; Title (croatian): Uloga Notch signalnog puta u patogenezi jetrene fibroze; Title (english): The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis; Acronym: NOFIBRO; Leader: Tomislav Kelava; Jurisdiction: Croatia; Funding stream: Installation Research Projects
• Project: Number: IP-2020-02-2431; Title (croatian): Obnova timusa za preciznu medicinu u liječenju tumora i leukemija; Title (english): Thymus renewal for precision medicine in cancer and leukaemia treatment; Acronym: THYMINNOVA; Leader: Mariastefania Antica; Jurisdiction: Croatia; Funding stream: Research Projects
• Document URL: https://www.mdpi.com/1422-0067/25/15/8064
• Type of resource: Text
• Access conditions: Open access
• Created on: 2025-03-31 08:01:48