Proliferacijski indeks i mitotska aktivnost u adenomima hipofize

master's thesis

• Title (english): Proliferation index and mitotic activity in pituitary adenomas
• Author: Branko Petrović
• Mentor: Danijela Kolenc (mentor)
• Committee member: Sven Seiwerth (predsjednik povjerenstva)
• Committee member: Slavko Gašparov (član povjerenstva)
• Committee member: Danijela Kolenc (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract

Adenomi hipofize odgovorni su za 15% svih intrakranijalnih neoplazmi i
najčešći su uzrok hiposekrecije ili hipersekrecije hormona adenohipofize.
Najčešće se radi o benignim tumorima monoklonalnog podrijetla nastalih od
jedne od pet vrsta stanica adenohipofize. Određivanjem proliferacijskih
markera u adenomima želimo saznati vjerojatnost agresivnosti i lokalne
rekurentosti tumora, te je cilj ovog rada bilo odrediti karakteristike adenoma
hipofize s naglaskom na proliferacijski indeks Ki-67 i mitotsku aktivnost. U
istraživanje je uključeno ukupno 83 bolesnika liječena u KBC-u Zagreb. Kod
njih 95% nađen je makroadenom, dok je samo 5% imalo mikroadenom.
Mitotska aktivnost u svim tumorima bila je niska, dok je proliferacijski indeks
varirao od 0,7% do 10%. Kod trećine bolesnika indeks je bio iznad 3%.
Tumori s nižim vrijednostima Ki-67 bili su somatotropinomi i neaktivni
adenomi s medijanom od 2%, dok je kod kortikotropinoma i prolaktinoma
indeks bio oko 5%. Potrebna su daljnja istraživanja kojima bi se utvrdio utjecaj
ovih markera na invazivnost i rekurentnost adenoma.

Abstract (english)

Pituitary adenomas account for 15% of all intracranial neoplasms and
are the most common cause of pituitary hormone hyposecretion or
hypersecretion syndromes. These are benign tumors of monoclonal origin that
originate from one out of five types of pituitary cells. Probability of
aggressiveness and local recurrence of adenomas is determined with
proliferation markers. The aim of this study was to determine characteristics of
adenomas with the stress on proliferation index and mitotic activity. In this
research we analyzed data of 83 patients treated at the University Hospital
Centre Zagreb. Macroadenomas were found in 95% of cases, while 5% of
cases had microadenomas. Mitotic activity in all tumors was low, while
proliferation index varied from .7% to 10%. Third of patients had index above
3%. Somatotropinomas and nonfunctioning adenomas had lower levels of
Ki-67 with mean of 2%, and corticotropinomas and prolactinomas had a mean
of 5%. Further studies are needed in order to determine the effect of these
markers on invasiveness and local recurrence of adenomas.

• Keywords: adenomi hipofize; proliferacijski indeks; Ki-67; mitotska aktivnost
• Keywords (english): pituitary adenoma; proliferation index; Ki-67; mitotic activity
• Language: croatian
• URN:NBN: urn:nbn:hr:105:789037
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-06-29 12:36:29