Nadoknada krvnih derivata u masivnim krvarenjima

master's thesis

• Title (english): Patient blood management in massive blood loss
• Author: Mateja Ulamec
• Mentor: Daniela Bandić Pavlović (mentor)
• Committee member: Mladen Perić (predsjednik povjerenstva)
• Committee member: DINKO TONKOVIĆ (član povjerenstva)
• Committee member: Daniela Bandić Pavlović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Anesthesiology and Reanimatology

Abstract

Cilj je ovog rada dati pregled novih spoznaja o terapiji masivnog krvarenja pomoću krvnih derivata, ali i drugih pripravaka koji se koriste u toj situaciji. Masivno krvarenje definira se kao akutno i životno ugrožavajuće stanje u kojem je pacijent izgubio jedan cirkulirajući volumen krvi unutar 24 sata, više od 150ml krvi u minuti ili više od 50% ukupnog volumena krvi unutar 3 sata. Rad je podijeljen u tri dijela od kojih se svaki bavi drugim aspektom teme. Prvi dio se bavi definiranjem masivnog krvarenja te opisom procesa dobivanja i osnovnih obilježja krvnih derivata. Drugi dio je usredotočen na terapiju masivnog krvarenja, te je podijeljen u tri područja koja se bave patofiziologijom, samim postupkom masivne transfuzije i opisom farmakoloških pripravaka koji se također koriste u terapiji. Treći dio je usredotočen na najčešće komplikacije povezane s krvarenjem i masivnom transfuzijom te njihovo sprječavanje. Zaključak je iznesen u zadnjem djelu rada te predlaže sažeti postupak s pacijentom koji masivno krvari.

Abstract (english)

The goal of the thesis is to provide an overview of new insights into management of massive blood loss with blood components and other products used in the treatment. Massive blood loss is defined as an acute and life threatening condition where a person has lost one blood volume within a 24 hour period, more than 150ml of blood per minute or over 50% of blood volume in 3 hours. Thesis is composed of three parts, each of them dealing with different aspects. The first part sets the definition of massive bleeding, describes the process of making a blood components and their characteristics. The second part focuses on management of massive bleeding and is subdivided into three chapters dealing with pathophysiology, massive transfusion procedure and description of pharmacological products that are used in treatment. Third part focuses on most common complications of bleeding and massive transfusion and their management. Conclusions are drawn at the end, suggesting concise algorithm for a clinician facing a patient with a massive blood loss.

• Keywords: masivno krvarenje; masivna transfuzija; krvni derivati; komplikacije masivne transfuzije
• Keywords (english): massive bleeding; massive transfusion; blood components; complications of massive transfusion
• Language: croatian
• URN:NBN: urn:nbn:hr:105:876570
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-07-04 07:12:13