Važnost vitamina d za zdravlje

master's thesis

• Title (english): Importance of vitamin d for health
• Author: Dora Primorac
• Mentor: Duška Tješić-Drinković (mentor)
• Committee member: Irena Senečić-Čala (predsjednik povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Committee member: Duška Tješić-Drinković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

D vitamin je vitamin topljiv u mastima koji se tradicionalno povezuje sa zdravljem kostiju. Međutim, novija istraživanja su pokazala da sudjeluje u brojnim reakcijama u ljudskom tijelu, kao i u regulaciji oko 3% ljudskog genoma. Istodobno postoji sve više studija o raširenoj pojavi nedostatka D vitamina diljem svijeta. Ona zabrinjava u svjetlu novih spoznaja o važnoj ulozi D vitamina u bolestima kostiju i drugih sustava, kao što su prevencija rahitisa, poremećaji funkcije kostiju i mišića, prevencija autoimunih bolesti, zloćudnih bolesti, kardiovaskularnih bolesti, infekcija, neurofizioloških i reproduktivnih poremećaja.
Cilj ovog rada je objediniti najnovije podatke o dobrobiti unosa D vitamina i posljedicama njegovog nedostatka. Nadalje, iznesene su dvojbe oko optimalnih razina D vitamina u krvi i navedene aktualne smjernice za suplementaciju tog vitamina. Uzevši u obzir visoku prevalenciju nedostatka D vitamina diljem svijeta, te malu opasnost od trovanja njime, čini se da je danas puno realnija šteta od manjka nego od viška D vitamina.

Abstract (english)

Vitamin D is a fat soluble vitamin involved in numerous reactions in human body. Traditionally, it has been linked to bone health, but we are nowdays aware of its numerous extraskeletal effects and the fact that it regulates about 3% of human genome. Recent reports suggest not only a higher recognition of vitamin D deficiency worldwide, but also various health benefits from vitamin D supplementation. Vitamin D plays an important role in skeletal and extra-skeletal disease areas, such as bone and muscular disfunction, well-known prevention of rickets, prevention of autoimmune diseases, malignancy, cardiovascular diseases, infections, neurophysiological disorders and reproductive disorders.
The aim of this paper is to summarize the latest data on benefits of vitamin D intake and consequences of its deficiency. In addition, doubts on optimal vitamin D blood level and recent guidelines for its supplementation are pointed out. Having in mind high prevalency of vitamin D deficiency and its insignificant intoxication risk, nowdays the damage from vitamin D deficit seems to be more realistic than the damage from its excess.

• Keywords: D vitamin; koštani učinci; izvankoštani učinci; nedostatak; suplementacija
• Keywords (english): vitamin D; skeletal effects; extraskeletal effects; deficiency; supplementation
• Language: croatian
• URN:NBN: urn:nbn:hr:105:128859
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-16 07:30:58