Izlučivanje oksalata,citrata i glikozaminoglikana mokraćom u djece s urolitijazom

master's thesis

• Title (english): Urinary excretion of oxalate, citrate, glycosaminoglycans in children with urolithiasis
• Author: Daniel Turudić
• Mentor: Danica Batinić (mentor)
• Committee member: Ernest Bilić (predsjednik povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Committee member: Danica Batinić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Analizirano je izlučivanje urinom oksalata, citrata i glikozaminoglikana u 83 djece s idiopatskom urolitijazom. Iz analize su isključene primarne hiperoksalurije i idiopatske hiperokslurije (HOGA 1) koje su uzrokovane mutacijama gena i enteričkom hiperoksalurijom. Kao varijable su uzete koncentracije oksalata, citrata i glikozaminoglikana te omjeri oksalati/citrati, oksalati/glikozaminglikani, oksalati/(citrati × glikozaminoglikani) i citrati/glikozaminoglikani. Od ispitanih varijabli jedino je omjer oksalati/(citrati × glikozaminoglikani) mmol/mol kreatinina razlikovao zdravu djecu od skupine djece s uirolitijazom. ROC analizom je utvrđeno da je vrijednost omjera > 0.0782 dijagnostički prihvatljiva za razlikovanje djece s urolitijazom od zdrave djece. Stoga se nalaz omjera oksalati/(citrati × glikozaminoglikani) iznad 0.0782 može se smatrati određujućim za djecu s urolitijazom.

Abstract (english)

Urinary excretion of oxalate, citrate, glycosaminoglycans and the ratios oxalate/citrate, oxalate/glycosaminoglycans, oxalate/(citrate × glycosaminoglycans), and citrate/glycosaminoglycans were examined in 83 children with idiopathic urolithiasis. Gene mutations causing primary hyperoxaluria and idiopathic hyperoxaluria HOGA 1 were excluded. Only the variable oxalate/(citrate × glycosaminoglycans) mmol/mol creatinine was able to distinguish between children with urolithiasis and healthy children. ROC analysis showed that the value of the ratio > 0.0782 is adequate for diagnostic purpose. Therefore, we consider that the ratio oxalate/(citrate × glycosaminoglycans) above 0.0782 indicates urolithiasis in children.

• Keywords: idiopatska urolitijaza; omjer oksalati/(citrati × glikozaminoglikani); djeca
• Keywords (english): idiopathic urolithiasis; oxalate/(citrate × glycosaminoglycans) ratio; children
• Language: croatian
• URN:NBN: urn:nbn:hr:105:052646
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-18 09:12:57