Hemoragijske i tromboembolijske komplikacije kod pacijenata s postkardiotomijskom izvantjelesnom membranskom oksigenacijom

master's thesis

• Title (english): Hemorrhagic and thromboembolic complications in patients with postcardiotomic extracorporeal membrane oxygenation
• Author: Marija Vrankić
• Mentor: Hrvoje Gašparović (mentor)
• Committee member: Davor Mijatović (predsjednik povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Committee member: Hrvoje Gašparović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2016-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Cilj je ovog istraživanja bio opisati dolazi li, i u kojem razmjeru, do tromboembolijskih i hemoragijskih komplikacija kod pacijenata na postkardiotomijskom ECMO-u.
U istraživanje je uključeno 42 pacijenata iz bolničke populacije, od kojih je bilo 24 muškaraca i 18 žena. Svi su ti pacijenti bili podvrgnuti kardijalnim operacijama te im je ECMO ugrađen u kritičnim periodima hemodinamske nestabilnosti. To su, uz komplikacije izazvane od strane ECMO-a, također bitne okolnosti koje su doprinijele komplikacijama i mortalitetu.
Kao pokazatelj opsega najčešće komplikacije (krvarenja), praćena je količina transfundiranih koncentrata eritrocita. Bilježeni su također vrijeme trajanja potpore, pozitivni mikrobiološki nalazi krvi, pojava ishemije noge, plućne embolije i krvarenja iz probavnog trakta te pojava krvarenja iz glave i vrata. Uz određivanje učestalosti navedenih komplikacija, određen je i mortalitet.
Rezultati istraživanja su pokazali korelaciju između trajanja potpore i transfuzije koncentrata eritrocita te prikazali učestalost navedenih komplikacija u navedenoj skupini pacijenata.
Usprkos invazivnosti ove metode i njezinim potencijalno teškim posljedicama, njezin je značaj vrlo velik s obzirom na to da bi velika većina ovih pacijenata umrla bez uvođenja ECMO-a zbog svojeg inicijalnog stanja u trenutku njegove ugradnje.

Abstract (english)

The aim of this research was to describe if and to what extent thromboembolic and hemorrhagic complications occur in patients with postcardiotomic ECMO.
The research included 42 patients from hospital population out of which 24 men and 18 women. All patients underwent cardiac surgeries and had ECMO implanted in critical periods of hemodynamic instability. Apart from complication caused by ECMO, these were also important circumstances contributing to complications and mortality.
The volume of transfused red blood cells was observed as an indicator of the scope of the most common complication (hemorrhaging). Duration of support, positive hemocultures, occurrence of leg ischemia, pulmonary embolism, hemorrhaging from gastrointestinal system and hemorrhaging from head and neck were also noted. Both frequency of previously mentioned conditions and mortality were determined.
The results showed the correlation between the duration of support and red blood cells as well as the frequency of the previously mentioned complications in this particular group of patients.
Despite the invasiveness of this method and its potentially serious consequences, its significance is great since most of these patients would have died without ECMO implantation due to their underlying conditions at the moment of its implantation.

• Keywords: postkardiotomijski; ECMO; komplikacije
• Keywords (english): postcardiotomy; ECMO; complications
• Language: croatian
• URN:NBN: urn:nbn:hr:105:095684
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-08-18 10:18:16