Otoskleroza

master's thesis

• Title (english): Otosclerosis
• Author: Ana Tomas
• Mentor: Srećko Branica (mentor)
• Committee member: Mario Bilić (predsjednik povjerenstva)
• Committee member: Mirko Ivkić (član povjerenstva)
• Committee member: Srećko Branica (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Otoskleroza je metabolička koštana bolest labirintne kapsule i pločice stremena te je jedan od najčešćih uzroka stečenog gubitaka sluha. Najčešće se javlja među bijelom populacijom s incidencijom od 1%, a žene su pogođene dva puta češće od muškaraca. Smatra se da je otoskleroza multifaktorska bolest, uzrokovana genetičkim i okolišnim čimbenicima. Nasljeđuje se autosomno dominantnim načinom s varijabilnom penetracijom. Uloga autoimunosti, virusa, hormona i mnogih drugih faktora u etiopatogenezi bolesti je predmet brojnih istraživanja, ali je točan uzrok otoskleroze još uvijek nepoznat.
Vodeći simptom otoskleroze je progresivna provodna nagluhost, ali se može javiti i šum te jako rijetko vrtoglavica. Bolest se obično prezentira između drugog i petog desetljeća života. Dijagnoza se temelji na anamnezi, kliničkom pregledu i ispitivanju sluha. Audiometrija tipično pokazuje provodnu nagluhost sa širim razmakom zračno-koštane krivulje u nižim frekvencijama. Kada postoji fiksacija stremena, odsutan je stapedijski refleks. Konzervativna terapija natrijevim flouridom može samo usporiti napredovanje bolesti pa se preferira kirurška terapija. Kirurške tehnike koje se koriste u terapiji otoskleroze su totalna i parcijalna stapedektomija i stapedotomija.

Abstract (english)

Otosclerosis is a disease affecting the bony metabolism of the otic capsule and stapes footpalate, and is among the most common causes of acquired hearing loss. It occurs most commonly among Caucasians with an incidence of 1%, and women are affected twice as often as men. Otosclerosis is considered a multifactor disease, caused by both genetic and environmental factors. It is inherited in an autosomal dominant pattern with incomplete penetrance. The role od autoimmunity, viruses, hormones and many other factors in the etiopathophysiology of disease has been subject of recent studies, but the exact cause of otosclerosis is unknown.
Progressive conductive hearing loss is the predominant symptom but patients also present with tinnitus and, rarely, dizziness. The clinical presentation usually occurs between the second and fifth decades of life. The diagnosis is based on medical history, clinical features, and hearing tests. The audiometric exam typically shows conductive hearing loss with a wider air-bone gap at lower frequencies. The stapedial reflex is absent when stapedial fixation is present. As medical treatment with sodium fluoride can only slow down the progression of disease, surgical management is preferred. Approaches to surgical management include total stapedectomy, partial stapedectomy, and stapedotomy.

• Keywords: otoskleroza; provodna nagluhost; stapedektomija; stapedotomija
• Keywords (english): otosclerosis; conductive hearing loss; stapedectomy; stapedotomy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:728612
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-10-19 10:36:03