Kolangiokarcinom

master's thesis

• Title (english): Cholangiocarcinoma
• Author: Iskra Pezdirc
• Mentor: MATE ŠKEGRO (mentor)
• Committee member: Ante Gojević (predsjednik povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Committee member: MATE ŠKEGRO (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery

Abstract

Kolangiokarcinom zloćudni je tumor nastao iz epitela žučnog sustava. Anatomski, dijeli se na intrahepatalni kolangiokarcinom, hilarni kolangiokarcinom i distalni ekstrahepatalni kolangiokarcinom. Kolangiokarcinom tumor je s vrlo lošom prognozom i niskim petogodišnjim preživljenjem. Prepoznati su brojni rizični čimbenici povezani s kolangiokarcinomom poput primarnog sklerozirajućeg kolangitisa, hepatolitijaze, infestacije nekim parazitima i ciroze. Klinička slika vrlo često je nespecifična, a najčešće se prezentira bezbolnom žuticom praćenom općim simptomima poput gubitka na težini, gubitka apetita, mučninom i povraćanjem. Povišenje CA 19-9 može ukazivati na zloćudni proces žučnih vodova. Radiološke tehnike poput ultrazvuka, višeslojne kompjuterizirane tomografije, magnetske rezonance te endoskopske retrogradne kolangiopankreatografije, ključne su za postavljanje dijagnoze kolangiokarcinoma. Kirurška resekcija jedina je potencijalno kurativna metoda ovoga tumora. Ukoliko je tumor neresektabilan, može se pokušati drugim oblicima liječenja poput kemoterapije ili radioterapije. U ovom radu prikazana je analiza 28 pacijenata liječenih na Zavodu za hepatobilijarnu kirurgiju i transplantaciju abdominalnih organa Kliničkog bolničkog centra Zagreb u periodu od 2011. do 2015. godine pod dijagnozom kolangiokarcinoma te radiološke tehnike koje su se najčešće koristile za postavljanje dijagnoze. Dobiveni rezultati ukazuju na potrebu za boljim praćenjem međunarodnih smjernica prilikom utvrđivanja dijagnoze kolangiokarcinoma različitim radiološkim tehnikama kako bi se povećala točnost dijagnoze i poboljšao konačni ishod liječenja.

Abstract (english)

Cholangiocarcinoma is a tumor derived from epithelial cells found in biliary system. Classification based on anatomical location includes intrahepatic cholangiocarcinoma, hilar cholangiocarcinoma and distal extrahepatic cholangiocarcinoma. Cholangiocarcinoma is a tumor with poor five year survival and very bad outcome. Risk factors such as primary sclerosing cholangitis, hepatolithiasis, parasite infestation and cirrhosis, are being associated with emergence of cholangiocarcinoma. Clinical presentation is often atypical. Most common signs are painless jaundice accompanied by general symptoms such as weight and appetite loss, nausea and vomiting. A raise in CA 19-9 levels may indicate malignancy of biliary origin. Radiologic techniques such as ultrasound, multislice computed tomography, magnetic resonance and endoscopic retrograde cholangiopancreatography are essential in diagnosis of cholangiocarcinoma. Surgical resection is the only potentially curative method for this tumor. If the tumor can`t be removed surgically, other treatments such as chemotherapy or radiotherapy could be used. In this paper we analyzed 28 patients who were treated from 2011 to 2015 under the diagnosis of cholangiocarcinoma and the most common radiologic techniques used for diagnosis in the Department for hepatobiliary surgery and transplantation of abdominal organs of University Hospital Centre Zagreb. Results suggest the need for better implementation of international protocols when diagnosing cholangiocarcinoma with different radiologic techniques. This way, diagnosis may be more accurate and overall outcome much better.

• Keywords: intrahepatalni kolangiokarcinom; hilarni kolangiokarcinom; distalni ekstrahepatalni kolangiokarcinom; radiološke tehnike
• Keywords (english): intrahepatic cholangiocarcinoma; hilar cholangiocarcinoma; distal extrahepatic cholangiocarcinoma; radiologic techniques
• Language: croatian
• URN:NBN: urn:nbn:hr:105:268552
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-13 10:15:07