Praćenje remisije kronične mijeloične leukemije nakon prekida terapije

master's thesis

• Title (english): Chronic myeloid leukemia remission follow up after therapy discontinuation
• Author: Nikolina Matić
• Mentor: Ana Boban (mentor)
• Committee member: Nadira Duraković (predsjednik povjerenstva)
• Committee member: Marko Jakopović (član povjerenstva)
• Committee member: Ana Boban (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2017-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Kronična mijeloična leukemija (KML) specifična je zloćudna bolest s obzirom da je liječenje moguće provoditi peroralnim uzimanjem lijekova. Liječenje KML-a se bazira na dugogodišnjoj terapiji inhibitorima tirozin kinaze (TKI). Redovitom i pravilnom upotrebom ovog lijeka veliki broj bolesnika postiže remisiju bolesti, pri čemu je u uspjehu liječenja iznimno važan čimbenik suradljivost bolesnika u odnosu na redovitu primjenu lijeka i medicinske kontrole. Rutinska praksa podrazumijeva korištenje TKI i nakon što bolesnik postigne potpunu remisiju bolesti, no recentna znanstvena istraživanja navode uspjeh u održavanju zdravstvenog stanja i kontroli bolesti i nakon što se prekine terapija s TKI. Svrha ovoga rada je sustavnim pregledom literature prikupiti relevantne znanstvene činjenice o uspješnosti održavanja remisije KML nakon prekida terapije TKI.

Abstract (english)

Chronic myeloid leukaemia (CML) is a specific malignant disease as it can be managed by oral treatment. The patients with CML are treated by a long term tyrosine-kinase inhibitors (TKI). The remission of the disease can be achieved in majority of patients, and the tretment results depend largely on patient's compliance and regular taking of TKI. Current routine practise in themanagement of CML includes continuation of TKI therapy even after patient achieves deep remision. However, recent studies suggested that the disease can remain in remision even after the TKI discontinuation. The aim of this thesis is to asses of relevant scientific evidence on CML remission stability after TKI therapy cessation.

• Keywords: kronična mijeloična leukemija; inhibitori tirozin kinaze; prekid
• Keywords (english): chronic myeloid leukaemia; tyrosine-kinase inhibitors; discontinuation
• Language: croatian
• URN:NBN: urn:nbn:hr:105:527097
• Study programme: Title: Studies in Nursing; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra sestrinstva (magistar/magistra sestrinstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-03-21 11:06:21