Volumetrija kranio-spinalnog sustava

master's thesis

• Title (english): Volumetry of cranio - spinal system
• Author: Luka Filipović-Grčić
• Mentor: Marijan Klarica (mentor)
• Committee member: Milan Radoš (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Marijan Klarica (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pharmacology); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Pharmacology

Abstract

Kranio-spinalni prostori proučavaju se otkako je medicine. Još je egipatski svećenik-liječnik Imhotep prepoznao postojanje cerebrospinalnog likvora. Tijekom većeg dijela povijesti likvor je bio zanemaren, uglavnom zbog svoje nedostupnosti unutar koštanog oklopa lubanje. Tek su nove slikovne metode kao što su kompjutorizirana tomografija i magnetna rezonancija omogućili uvid u procese, anatomiju i fiziologiju kranio-spinalnog prostora, a posebice cerebrospinalnog likvora. Postojeća dogma o njegovom stvaranju, cirkuliranju i apsorpciji koja traje zadnjih stotinu godina polako se preispituje. Spoznaje koje su donijele nove metode bacaju novo svjetlo na njegova svojstva i moguće implikacije i primjene u medicini. Likvor je toliko kontroverzna medicinska tema da znanost još uvijek odgovara na osnovna pitanja poput prave količine likvora u zdravih pojedinaca. Polje istraživanja cerebrospinalnog likvora jedno je od rijetkih područja medicine gdje hrvatski znanstvenici stoje uz bok svjetskim autoritetima i neizostavni su dio svake rasprave o toj temi. Zbog svoje neinvazivne prirode i relativne neškodljivosti metode kompjutorizirane tomografije i magnetne rezonancije postale su osnovni alat u proučavanju kranio-spinalnog prostora, zaista, većina istraživanja koriste upravo ove metode. Stoga će ovaj rad ponuditi pregled njihovog razvoja i primjene na tom području, kao i rezultate koje su polučile.

Abstract (english)

Cranio-spinal space has been studied since the very eve of medicine. The oldest medical document, the Smith papyrus, has an entire section dedicated to cerebrospinal liquor. However, throughout the greater part of history, liquor was neglected by the scientists, largely due to it’s enclousure within the hard bony cast of the skull. Only recently did the new neuroimaging methods of computerized tomography and magnetic resonance enable the insight into the processes of liquor anatomy and physiology. The existing dogma concerning it’s formation, circulation and apsorption has ruled undisputed for over a century. Nowadays, this dogma is being questioned. The knowledge the new methods have brought along shed a new light on it’s qualities and possible applications in medicine. However, liquor is still such a controversial theme that science hasn’t even figured out how much of it there is in a healthy individual. The field of liquor research is one of rare fields in medicine where Croatian scientists rank amongst the word authorities on the subject. Due to their noninvasiveness and nonmalleficience the methods of computerized tomography and magnetic resonance became an essential tool in liquor research and, indeed, most studies mentioned in this review are done by them. Therefore, this review hopes to describe their development and application on this field.

• Keywords: kranio-spinalna volumetrija; cerebrospinalni likvor; kompjutorizirana tomografija; magnetna rezonancija
• Keywords (english): cranio-spinal volumetry; cerebrospinal liquor; computerized tomography; magnetic resonance
• Language: croatian
• URN:NBN: urn:nbn:hr:105:691204
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-04 12:18:46