Specifičnosti zbrinjavanja intoksikacija novim psihoaktivnim tvarima

master's thesis

• Title (english): Specific management of intoxication with new psychoactive substances
• Author: Tena Čižmešija
• Mentor: Ingrid Prkačin (mentor)
• Committee member: Ivan Gornik (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Ingrid Prkačin (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Clinical Pharmacology and Toxicology

Abstract

Posljednjih godina pratimo trend porasta popularnosti novih psihoaktivnih tvari (NPS), osobito među mlađom populacijom. Dostupnost ovih tvari na internetu i različitim specijaliziranim trgovinama moguća je zbog nedostataka legislative koja ne može uhvatiti korak sa stalnom proizvodnjom novih spojeva koji izmiču zakonskoj kontroli. Mnoštvo spojeva i nemogućnost njihova otkrivanja klasičnim toksikološkim analizama uzroci su manjku informacija o kliničkoj slici i optimalnom načinu liječenja intoksikacija. Izolirani prikazi slučajeva i retrospektivne epidemiološke analize serija slučajeva osnova su onoga što trenutno znamo o različitim skupinama NPS, njihovim učincima te kako postupati u slučajevima intoksikacija. Osnivanje nacionalnog sustava ranog upozoravanja (EWS) bio je prvi potreban korak u rješavanju problema centraliziranog prikupljanja podataka, ali sada je potreban daljnji rad na suradnji različitih subjekata koji će omogućiti sakupljanje i obradu informacija te prikazati stvarno stanje u Republici Hrvatskoj u realnom vremenu. Osim nacionalne, razmjena informacija moguća je i na internacionalnoj razini putem europske mreže sustava ranog upozoravanja, Europskog centra za praćenje droga i ovisnosti o drogama (EMCDDA) i ostalih institucija na razini Europske Unije (EU) što omogućuje izdavanje upozorenja o opasnim tvarima brzo nakon njihove pojave i akcije na nacionalnoj razini ako je to potrebno. Zbog nemogućnosti toksikološke analize NPS u uzorcima i manjkavosti u sustavu prikupljanja informacija u Hrvatskoj, radi se na implementaciji protokola postupanja, organizaciji mreže laboratorija i opremanju referentnog laboratorija što će omogućiti dokazivanje NPS u biološkim uzorcima i formiranje vlastite baze podataka o intoksikacijama.

Abstract (english)

Recently, there has been a noticeable rise in popularity of new psychoactive substances (NPS), especially among the younger population. Availability of these substances on the internet and in different specialized shops is possible because of the lack of legislation, which can not keep up with the constant production of new compounds that evade legal control. Many different compounds and the inability of their detection using classical toxicology analyses are the main causes of the last of information on clinical presentation and the optimal management of the intoxications. Isolated case reports or retrospective epidemiological studies of case series provide the basis of our current knowledge about different groups of NPS, their effects and treatment options for intoxicated patients. Establishing the national Early Warning System (EWS) has been the first step in solving the problem of centralised data collection, however, it is currently necessary to stimulate cooperation between various subjects to enable information collection and analysis, thereby allowing real time situational overview in Croatia. Apart from the national informational exchange, sharing of information is also available at the international level via the European information network on drugs and drug addiction (Reitox), European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and other EU institutions, which allows for prompt warning issuance on dangerous substances and expeditious action on national levels if necessary. Because of the inability to detect NPS in biological samples and unsatisfactory data collection in Croatia, implementation of treatment algorithm, laboratory network and establishment of the referral laboratory are all under way and these actions will result in ability to detect NPS as well as formation of Croatian national database on NPS intoxications.

• Keywords: nove psihoaktivne tvari; intoksikacija; hitna stanja
• Keywords (english): new psychoactive substances; intoxication; emergency
• Language: croatian
• URN:NBN: urn:nbn:hr:105:231460
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-09 07:48:15