Comparison of treatment options of uveitis in juvenile idiopathic arthritis

master's thesis

• Title (croatian): Komparacija načina liječenja uveitisa u juvenilnom idiopatskom artritisu
• Author: Nataša Basrak
• Mentor: Nenad Vukojević (mentor)
• Committee member: Nenad Vukojević (predsjednik povjerenstva)
• Committee member: Tomislav Jukić (član povjerenstva)
• Committee member: Miro Kalauz (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2017-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Ophthalmology

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children and it affects approximately 1 in 1000 children worldwide. Children with JIA have an increased risk for uveitis and as many as 10-30% of children with JIA will develop uveitis. Severe or untreated uveitis can lead to long term complications and consequences, including cataracts, glaucoma and blindness; therefore treatment is of utmost importance. Topical corticosteroids and systemic immunosuppressants have been treatment of choice, however recently biologic agents have been used. An exploration of numerous clinical trials concerning the treatment of uveitis in JIA patients is necessary to conclude what the newest gold standard treatment should be. Specifically, a comparison of immunosuppressants alone versus a combination with biologic agents should be explored to deduce which is the most beneficial for treatment and if there is a difference in extent or type of side effects. Considering the high incidence level of this illness and the potential consequences if treatment is not provided, there is great importance in reviewing multiple clinical trials and concluding what the current treatment algorithm should be. This review aims to explore the current medical treatment of JIA –associated uveitis and the effectiveness and safety of the drugs involved.

Abstract (croatian)

Juvenilni idiopatski artritis (JIA) najčešća je kronična reumatološka bolest kod djece i javlja se otprilike kod 1 od 1000 djece diljem svijeta. Djeca s JIA imaju povećani rizik za uveitis i čak 10-30% djece s JIA-om će razviti uveitis. Teški oblik uveitisa ili neliječeni uveitis može dovesti do dugoročnih komplikacija i posljedica, uključujući kataraktu, glaukom i sljepoću; stoga je liječenje od najveće važnosti. Topički primijenjeni kortikosteroidi i sustavni imunosupresivi lijekovi su izbora, no u posljednje vrijeme koriste se biološki lijekovi. Analizom brojnih kliničkih ispitivanja vezanih uz liječenje uveitisa u pacijenata s JIA-om potrebno je zaključiti koji bi bio najnoviji standard u liječenju ove bolesti. Posebno, treba usporediti uporabu imunosupresiva samih u odnosu na kombinaciju s biološkim lijekovima kako bi se utvrdio koji je lijek najkorisniji za liječenje i utvrditi razliku u opsegu i vrsti nuspojava. S obzirom na visoku incidenciju ove bolesti i potencijalne posljedice neliječene bolesti, velika je važnost u analizi višestrukih kliničkih ispitivanja i zaključivanju, što bi trebao biti trenutni algoritam liječenja. Cilj ovog preglednog rada je istražiti suvremeno liječenje JIA-udruženog uveitisa te učinkovitosti i sigurnost lijekova koji su uključeni u liječenje.

• Keywords: uveitis; JIA
• Keywords (croatian): uveitis; JIA
• Language: english
• URN:NBN: urn:nbn:hr:105:546465
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-19 07:15:24