Recent advances in understanding the pathogenesis of rosacea

master's thesis

• Title (croatian): Suvremene spoznaje u patogenezi rozaceje
• Author: Ibad Ahmad Faruqui
• Mentor: Zrinka Bukvić Mokos (mentor)
• Committee member: Zrinka Bukvić Mokos (predsjednik povjerenstva)
• Committee member: Branka Marinović (član povjerenstva)
• Committee member: Krešimir Kostović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2017-09-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Rosacea is a common, chronic inflammatory skin disease that affects the central portions of the face, such as forehead, the chin and the lower half of the nose. This graduate thesis will delve into the existing scientific literature that attempts to recognize the pathophysiologic pathways leading to rosacea manifestation. Even though rosacea is one of the most common conditions encountered by dermatologists worldwide, the etiopathogenesis of this inflammatory disease remains somewhat of a mystery. Researches dedicated to epidemiological investigations undeniably point towards a genetic factor; however, no “rosacea gene” has been recognised to date. Although rosacea has a high prevalence among fair-skinned individuals, recent reports show that it can occur in other skin phenotypes as well. While four clinical subtypes have been designated, it is still unknown if the subtypes are a representation of the different developmental stages of the disease or simply manifestations of a syndrome that clinically overlap. This paper classified pathophysiological mechanisms of rosacea as either being the outcome of innate immune dysfunctions, neuroimmune and neurovascular interactions, ultraviolet radiation, and lastly, microbial causation. Many investigative and observational studies have been undertaken in the past few decades to pinpoint the precise pathophysiological pathway, especially clarifying the pivotal role of innate immunity dysfunction in the development of rosacea.

Abstract (croatian)

Rozaceja je česta kronična bolest koja zahvaća središnji dio lica, uključujući čelo, bradu i donji dio nosa. Ovaj diplomski rad obuhvatit će pregled znanstvene literature kojom su se pokušali prepoznati patofiziološki putovi koji dovode do manifestacije rozaceje. Iako je rozaceja jedna od najčešćih bolesti s kojima se susreću dermatolozi širom svijeta, etiopatogeneza ove upalne bolesti ostaje svojevrsna zagonetka. Istraživači, koji su provodili epidemiološka istraživanja, nedvojbeno ukazuju na genetski čimbenik; međutim, do danas nije otkriven „gen za rozaceju“. Iako rozaceja ima visoku prevalenciju među osobama sa svijetlim tenom, nedavna izvješća pokazuju da se može pojaviti i kod drugih kožnih fenotipova. Iako se razlikuju četiri klinička podtipa bolesti, još uvijek nije jasno radi li se o različitim razvojnim fazama bolesti ili jednostavno manifestacijama jednog sindroma koje se klinički preklapaju. U ovom radu klasificirani su patofiziološki mehanizmi rozaceje, uključujući poremećaj funkcije urođene imunosti, neuroimune i neurovaskularne interakcije, ultraljubičasto zračenje i, konačno, mikroorganizme kao etiološke čimbenike. U posljednjih nekoliko desetljeća provedena su brojna istraživanja i opservacijske studije kako bi se utvrdio precizan patofiziološki mehanizam bolesti, osobito pojašnjavajući ključnu ulogu poremećaja urođene imunosti u razvoju rozaceje.

• Keywords: rosacea; pathophysiology; innate immunity; vascular system; ultraviolet radiation
• Keywords (croatian): rozaceja; patofiziologija; urođena imunost; krvožilni sustav; ultraljubičasto zračenje
• Language: english
• URN:NBN: urn:nbn:hr:105:779969
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-04-24 11:27:54