Prevencija, prepoznavanje i prognoza vaskularnog kognitivnog poremećaja

master's thesis

• Title (english): Prevention, detection and prognosis of vascular cognitive impairment
• Author: Marina Rađenović
• Mentor: Branko Malojčić (mentor)
• Committee member: Zdravka Poljaković (predsjednik povjerenstva)
• Committee member: Mario Habek (član povjerenstva)
• Committee member: Branko Malojčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Neurology); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract

Vaskularni kognitivni poremećaj (eng. VCI = vascular cognitive impairment) je termin koji obuhvaća čitavi spektar kognitivnih poremećaja povezanih s cerebrovaskularnom bolešću (CVB), od vaskularnog blagog kognitivnog poremećaja (VaMCI=vascular
mild cognitive impairment) do vaskularne demencije (VaD). Trenutno je VCI drugi najčešći uzrok demencije, nakon Alzheimerove bolesti (AB). Rizični čimbenici za VCI se uglavnom preklapaju s rizičnim čimbenicima za moždani udar (MU). Dijagnostika se temelji na prepoznavanju kognitivnog poremećaja i CVB. VCI koji nije povezan s prethodnim MU je posljedica CVB koju je klinički teško otkriti, stoga značajnu ulogu u dijagnosticiranju VCI imaju magnetska rezonancija (eng. MRI = magnetic resonance imaging) i druge metode oslikavanja mozga. Kliničkom slikom prevladavaju poremećaji izvršnih funkcija dok poremećaji pamćenja tipični za AD ne moraju biti prisutni. Trenutno niti jedan lijek nije odobren za liječenje VCI, stoga je glavni način liječenja prevencija s ranim prepoznavanjem rizične populacija i agresivnim liječenjem rizičnih čimbenika.

Abstract (english)

Vascular cognitive impairment is a term that covers the entire spectrum of cognitive disorders associated with cerebrovascular disease (CVD), from vascular mild cognitive impairment (VaCMI) to vascular dementia (VaD). Currently, VaD is the second most frequent cause of dementia, after Alzheimer's disease. The risk factors for VCI are mostly overlapping with risk factors for stroke. The diagnostic approach is based on the detection of cognitive impairment and CVD. VCI not associated with previous stroke is the consequence of CVD which is clinically difficult to detect, therefore the magnetic resonance imaging (MRI) and other neuroimaging methods have a significant role in VCI diagnosis. The clinical presentation is typically dominated by deficits in executive function rather than the memory deficit typical of Alzheimer’s disease. Currently, there is no approved symptomatic treatment of VCI, so prevention with early recognition of populations at risk and aggressive management of risk factors remains the main treatment option.

• Keywords: vaskularni kognitivni poremećaj (VCI); cerebrovaskularna bolest (CVB); Alzheimerova bolest (AB); magnetska rezonancija (MRI)
• Keywords (english): vascular cognitive impairment; cerebrovascular disease; Alzheimer's disease; magnetic resonance imaging
• Language: croatian
• URN:NBN: urn:nbn:hr:105:355993
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-12-13 13:30:28