Melanomi kože

master's thesis

• Title (english): Skin melanomas
• Author: Ante Valdman
• Mentor: Davor Tomas (mentor)
• Committee member: Božo Krušlin (predsjednik povjerenstva)
• Committee member: Monika Ulamec (član povjerenstva)
• Committee member: Davor Tomas (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathology); Zagreb
• Defense date and country: 2018-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract

Melanom kože je maligni tumor koji nastaje zloćudnom preobrazbom epidermalnih melanocita, s tendencijom agresivnog metastaziranja, kroz limfni i krvožilni sustav. Može nastati iz prethodno prisutnih nevusa ili de novo, a očituje se kao promjene boje, oblika, veličine i oblika rubova lezija na koži, uz moguću prisutnost krvarenja, erozija, ulceracija i kliničkih znakova upale. Klinički izgled melanoma kože varira ovisno o načinu rasta i dijelu tijela na kojem nastaje. Ključni čimbenik u smanjenju rizika od smrtnog ishoda kod bolesnika s melanomom je njegovo rano otkrivanje, budući da je dubina neoplazme, koja se s vremenom povećava, izravno povezana s prognozom ishoda bolesti. Uz klinički pregled, anamnezu, dermatoskopiju i analizu melanomskih biljega, te imunološka testiranja, sve je važnije informiranje i obučavanje javnosti o koristima i metodama ranog otkrivanja melanoma samopregledom kože. Način liječenja kao i prognoza ishoda bolesti vezani su tijesno, osim uz obilježja pacijenta i tip melanoma i sa stadijem bolesti koja se određuje prema 8. AJCC klasifikaciji iz 2018. Opcije liječenja mogu biti kirurško odstranjenje, kemoterapija, radioterapija, fotodinamička terapija (PDT), imunoterapija, ili genetski ciljana terapija.

Abstract (english)

Cutaneous melanoma is a malignant tumor originating from malignant mutation of epidermal melanocytes, with the tendency of aggressive metastasizing both through lymphatic and vascular system. It can occur from previously present nevus or de novo and is manifested as changes in color, shape, dimension and borders of the skin lesions, potentially accompanied with bleeding, erosions, ulcerations and clinical signs of inflammation. Clinical manifestation of cutaneous melanoma varies, dependent on growth pattern and body part where it originates. Early diagnosis is the key factor in decreasing the risk of fatal outcome for melanoma patients, because the thickness of the neoplasm that grows with time is directly correlated with prognosis of the disease outcome. Along with clinical examination, patient history, dermatoscopy, analysis of melanoma markers and immunological testing, there is a growing importance of information and education of the public regarding benefits and methods for early melanoma detection by skin self-examination. Treatment approach, as well as prognosis of the disease outcome are closely related to disease stage which is determined according to 8th AJCC melanoma classification from 2018, as well as personal attributes of the patient and melanoma type. Therapeutic approaches can be surgical excision, chemotherapy, radiotherapy, photodynamic therapy (PDT), immunotherapy and genetically targeted therapy.

• Keywords: melanom; incidencija; klasifikacija; dijagnostika
• Keywords (english): melanoma; incidence; classification; diagnostics
• Language: croatian
• URN:NBN: urn:nbn:hr:105:408559
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-12-20 08:24:12