Trichomonas vaginalis infekcija u muškaraca s uretritisom

master's thesis

• Title (english): Trichomonas vaginalis infection in men with urethritis
• Author: Mislav Peras
• Mentor: Mario Sviben (mentor)
• Committee member: Sunčanica Ljubin Sternak (predsjednik povjerenstva)
• Committee member: Goran Tešović (član povjerenstva)
• Committee member: Mario Sviben (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Microbiology and Parasitology); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Medical Microbiology

Abstract

Trihomonoza je najčešća nevirusna spolno prenosiva bolest (SPB) uzrokovana flagelatnim protistom Trichomonas vaginalis. T. vaginalis striktno je ljudski patogen koji inficira urogenitalni trakt muškaraca i žena, a prenosi se s osobe na osobu putem bliskog kontakta genitalnih sluznica. Kliničke manifestacije trihomonoze mogu biti različite i variraju od asimptomatske do neugodno simptomatske bolesti. Najčešće uzrokuje uretritis u muškaraca te vaginitis i cervicitis u žena, međutim infekcija je vrlo često asimptomatska. T. vaginalis može u muškaraca uzrokovati balanopostitis, prostatitis, epididimitis, površinske penilne ulceracije, smanjenu pokretljivost spermija i neplodnost. Trihomonoza je isto tako povezana s povećanom transmisijom HIV-a. T. vaginalis infekcija često se istovremeno nalazi u kombinaciji s ostalim SPB. Incidencija trihomonoze premašuje stopu infekcije klamidijom i gonokokom zajedno. Procijenjene stope incidencije koje se spominju u literaturu su preniske, s obzirom na to da se trihomonoza ne prijavljuje u mnogim zemljama, da infekcija može biti asimptomatska pogotovo u muškaraca te da laboratorijski testovi koji se koriste u dijagnostici često nemaju zadovoljavajuću osjetljivost. Metode za dijagnostiku mogu se podijeliti na izravne i neizravne. U izravne spadaju: mikroskopija, kultivacija, detekcija antigena i metode molekularne dijagnostike, dok u neizravne spada detekcija protutijela. Sistemna je terapija s 5-nitroimidazolima temelj liječenja trihomonoze, a preporučena terapija za liječenje T. vaginalis infekcije uključuje metronidazol ili tinidazol.

Abstract (english)

Trichomoniasis is the most common non-viral sexually transmitted infection (STI), and it is caused by the protozoan flagellate Trichomonas vaginalis. T. vaginalis is strictly human pathogen that infects the urogenital tracts of men and woman, and it is transmitted from person to person via close contact of genital mucosa. The clinical manifestations od trichomoniasis differ and can vary from asymptomatic infection to unpleasantly symptomatic infection. T. vaginalis most commonly causes urethritis in men and vaginitis and cervicitis in women; however, infections are often asymptomatic. T. vaginalis infection in men is associated with balanoposthitis, prostatitis, epididymitis, penile superficial ulceration decreased sperm cell motility, and infertility. Trichomoniasis is also associated with increased HIV transmission. Epidemiologically, T. vaginalis infections are commonly associated with other STIs. The incidence of trichomoniasis exceeds rates for gonorrhoea and chlamydial infection combined. The estimated infection rates cited in the literature may indeed be too low because trichomoniasis is not a retortable disease in many countries; the infection, particuraly in men, can be asymptomatic; and laboratory tests used for diagnosis often have inappropriate sensitivity. Laboratory diagnostic tests can be classified into direct and indirect. Direct tests are: microscopy, cultivation, antigen detection tests, and molecular diagnostic techniques; whereas indirect tests are antibody detection tests. Systemic treatement with 5-nitroimidazoles is the corestone of management of trichomoniasis, and the recommended treatement for T. vaginalis infection is metronidazole or tinidazole.

• Keywords: trihomonoza; spolno prenosiva bolest; uretritis; HIV; metronidazol
• Keywords (english): trichomoniasis; sexually transmitted infection; urethritis; HIV; metronidazole
• Language: croatian
• URN:NBN: urn:nbn:hr:105:822362
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-12-20 09:53:38