Pregled radova o ulozi dekompresijske kranijektomije u liječenju malignog edema mozga bolesnika s herpes simpleks virusnim encefalitisom

master's thesis

• Title (english): Review of papers on the role of decompressive craniectomy in the treatment of malignant brain edema in patients with herpes simplex viral encephalitis
• Author: Jan Šteter
• Mentor: Marija Santini (mentor)
• Committee member: Dalibor Vukelić (predsjednik povjerenstva)
• Committee member: Josip Begovac (član povjerenstva)
• Committee member: Marija Santini (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Infectious Diseases); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Infectology

Abstract

Herpes simpleks virus, s udjelom od 10-20%, najčešći je uzročnik virusnog encefalitisa. Iako je otkriće aciklovira značajno smanjilo smrtnost, 60-80% pacijenata ima trajne neuropsihijatrijske posljedice, uglavnom zbog razvoja nekroze i edema mozga. Uloga dekompresijske kranijektomije nedvojbeno je dokazana u liječenju malignog edema mozga nakon moždanog udara i traumatskih ozljeda mozga, a puni potencijal zahvata kod herpes simpleks virusnog encefalitisa tek treba istražiti. U ovom radu analizirani su svi do sada objavljeni prikazi slučajeva pacijenata oboljelih od herpes simpleks virusnog encefalitisa koji su zbog malignog edema mozga podvrgnuti dekompresijskoj kranijektomiji. Analiza prikazanih slučajeva doprinosi dosadašnjim saznanjima o pozitivnoj ulozi dekompresijske kranijektomije u smanjenju mortaliteta od malignog edema kao komplikacije encefalitisa i naglašava mogućnost boljeg ishoda kod pacijenata kod kojih je dekompresijska kranijektomija učinjena rano u vrijeme pogoršanja bolesti.

Abstract (english)

Herpes simplex virus, with a share of 10-20%, is the most common cause of viral encephalitis. Although the discovery of acyclovir significantly reduced mortality, 60-80% of patients have persistent neuropsychiatric deffects, mainly due to the development of necrosis and brain edema. The role of decompressive craniectomy is proven in the treatment of malignant brain edema following stroke and traumatic brain injury, but it's full potential in herpes simplex viral encephalitis is still to be investigated. This dissertation includes all previously published case reports that include patients with herpes simplex viral encephalitis who underwent decompressive craniectomy due to malignant brain edema. Case report analysis contributes to the present knowledge of the positive role of decompressive craniectomy in reducing mortality from malignant edema as a complication of encephalitis and emphasizes the possibility of better outcome in patients who underwent decompressive craniectomy early in the time of worsening of the disease.

• Keywords: herpes simpleks virus; encefalitis; edem mozga; dekompresijska kranijektomija
• Keywords (english): Herpes Simplex virus; encephalitis; brain edema; decompressive craniectomy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:834640
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2018-12-20 12:02:06