Nasljedni poremećaji metabolizma lipida

master's thesis

• Title (english): Inherited disorders of lipid metabolism
• Author: Patrik Martinjaš
• Mentor: Ivan Pećin (mentor)
• Committee member: Darko Kaštelan (predsjednik povjerenstva)
• Committee member: Ivančica Delaš (član povjerenstva)
• Committee member: Ivan Pećin (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2018-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Poremećaji metabolizma lipida, zajedno s trendom nezdrave prehrane, tjelesne neaktivnosti i pretilošću rezultiraju globalno proširenoj ubrzanoj aterosklerotskoj bolesti. Interakcija genetskih predispozicija, stečenih poremećaja lipoproteina i okolišnih čimbenika dovodi do rane koronarne bolesti srca, infarkta miokarda i moždanog udara. Kardiovaskularne bolesti vodeći su uzrok smrti u svijetu i kod muškaraca i žena pa je zbog toga ispravna dijagnostika i pravodobno liječenje ovih poremećaja od iznimne važnosti. Cilj ovog rada je prikazati dosadašnje spoznaje o nasljednim poremećajima metabolizma lipida. Rad je podijeljen u četiri dijela od kojih svaki opisuje drugi aspekt teme. Prvi dio opisuje osnovnu terminologiju i fiziološke procese metabolizma lipida. U drugom dijelu opisane su najčešće primarne dislipidemije i nekoliko vrlo rijetkih poremećaja metabolizma lipida. Treći dio sadrži dijagnostičke metode kojima se kliničari služe u otkrivanju ovih poremećaja. U četvrtom dijelu su navedene najčešće terapijske opcije u liječenju primarnih dislipidemija.

Abstract (english)

Lipid metabolism disorders, along with an unhealthy diet, physical inactivity and obesity, result in a globally extended, accelerated atherosclerotic disease. Interactions of genetic predisposition, acquired lipoprotein disorders and environmental factors lead to early coronary heart disease, myocardial infarction and stroke. Cardiovascular diseases are the main cause of death in the world for both men and women, and therefore the proper diagnosis and timely treatment of these disorders are of exceptional importance. The aim of this graduate thesis is an overview of the current knowledge about hereditary disorders of lipid metabolism. This overview is divided into four parts each describing another aspect of the theme. The first part describes basic terminology and physiological processes in lipid metabolism. The second part describes the most common primary dyslipidemia and several rare disorders of lipid metabolism. The third part focuses on the diagnostic methods used by clinicians to detect these disorders. The fourth part lists the most common therapeutic options for treating primary dyslipidemia.

• Keywords: lipoprotein; kolesterol; dislipidemija; obiteljska hiperkolesterolemija; obiteljska hipertrigliceridemija; liječenje dislipidemija
• Keywords (english): lipoprotein; cholesterol; dyslipidemia; familial hypercholesterolemia; familial hypertriglyceridemia; dyslipidemia therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:582355
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-01-10 09:46:19