Title Mikrobiom kože i akne Title (english) Skin microbiome and acne Author Stjepan Patrun Mentor Zrinka Bukvić Mokos (mentor)Committee member Branka Marinović (predsjednik povjerenstva)Committee member Romana Čeović (član povjerenstva)Committee member Zrinka Bukvić Mokos (član povjerenstva)Granter University of Zagreb Defense date and country 2019-07-12, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Acne vulgaris kronična je upalna dermatoza koja zahvaća pilosebacealnu jedinicu, odnosno seborejična područja kože poput lica, leđa i prsa. Oba spola podjednako su zahvaćena ovom bolešću, no teži oblici bolesti obično se jave u muškog spola. U patogenezi akne ključna su četiri čimbenika: povećano izlučivanje loja, poremećaj proliferacije keratinocita pilosebacealne jedinice, prisutnost Cutibacterium acnes (C. acnes) i upalni odgovor. Novija istraživanja ukazuju na značaj promjene ravnoteže mikrobioma kože na etiopatogenezu akne. Pri tome dominantnu ulogu ima C. acnes, gram–pozitivna, fakultativno anaerobna i lipofilna bakterija koja se u pilosebacealnom folikulu bolesnika s akne nalazi u povećanom broju, s obzirom na pojačano lučenje loja i okluziju folikula. Metagenomskim analizama utvrđeno je kako filotip IA dominantna kultura kod bolesnika s akne dok su sojevi podskupina IB, II i III dominantni na zdravoj koži, te mogu imati ulogu u oportunističkim infekcijama kože. C. acnes djeluje ne samo proinflamatorno, već i na lipogenezu i produkciju loja, te na poremećaj keratinizacije u folikulu. Također, C. acnes ima sposobnost stvaranja biofilma i to češće u oboljelih od akne. Biofilm doprinosi antimikrobnoj rezistenciji te potiče upalni odgovor. U folikularnom sadržaju prisutne su i druge vrste mikroorganizama, Malassezia spp. i različite vrste stafilokoka. Njihov utjecaj na patogenezu akne još nije u potpunosti utvrđen, ali poznato je da Malassezia pokazuje jaku aktivnost lipaze te da naseljava seborejična područja kože, dok Staphylococcus epidermidis u folikularnom sadržaju pokazuje antimikrobna svojstva prema C. acnes. No, potrebna su daljnja istraživanja utjecaja mikrobioma na fiziologiju kože i patogenezu pojedinih dermatoza.
Abstract (english) Acne vulgaris is a complex inflammatory dermatosis affecting pilosebaceous unit of seborrheic skin areas including face, back and chest. Both sexes are equally affected, but the severe types of acne affect men significantly more often than women. Pathogenesis of acne includes four key factors: increased sebum production (seborrhea), hypercornification of the pilosebaceous follicle, colonization of the pilosebaceous follicle by Cutibacterium acnes (C. acnes) and inflammatory response. The latest data indicate the role of skin microbiome changes in acne etiopathogenesis. C.acnes, gram-positive, facultative anaerobic and lipophilic bacteria has the greatest impact on acne. It dominates in follicles and leads to increased sebum production and follicle occlusion. Metagenomic analyses have shown that IA phylotype dominates on acne affected skin, while phylotypes IB, II and III dominate on healthy skin and might have a role in opportunistic skin infections. C. acnes leads to inflammation, impacts lipogenesis and sebum production, as well as follicle cornification process. Furthermore C. acnes produces biofilm, particulary in acne affected skin. Biofilm contributes to resistance to antibiotic treatments and participates in inflammatory response. Malassezia spp. and different staphylococcus species also colonize follicles, but their role in acne pathogenesis remains unclear. Malassezia spp., which colonizes seborrheic skin areas, shows significant lipase activity, while Staphylococcus epidermidis has a negative impact on C. acnes proliferation in follicles. Further exploration of skin microbiome and it's role in skin physiology and certain skin condition is necessary.
Keywords
akne
mikrobiom kože
Cutibacterium acnes
Keywords (english)
acne
skin microbiome
Cutibacterium acnes
Language croatian URN:NBN urn:nbn:hr:105:069590 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2019-10-30 09:17:47
