Epidemiološke, kliničke i laboratorijske osobnosti infekcija donjih dišnih puteva uzrokovanih respiratornim sincicijskim virusom i humanim metapneumovirusom

master's thesis

• Title (english): Epidemiological, clinical and laboratory aspects of lower respiratory system infections caused by respiratory syncytial virus and human metapneumovirus
• Author: Ante Mazalin
• Mentor: Goran Tešović (mentor)
• Committee member: Dalibor Vukelić (predsjednik povjerenstva)
• Committee member: Josip Begovac (član povjerenstva)
• Committee member: Goran Tešović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Infectious Diseases); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Infectology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Epidemiology
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Respiratorni sincicijski virus i humani metapneumovirus važni su uzročnici akutnih infekcija donjeg dišnog sustava u dojenčadi i male djece. RSV primoinfekcija se najčešće javlja u djece između drugog i osmog, a hMPV između šestog i tridesetog mjeseca života. Epidemije RSV-a se javljaju u bianualnim ciklusima, kao veća epidemija zimi koju slijedi manja u proljeće sljedeće godine, a hMPV uglavnom prati ovakav obrazac pojavljivanja. Cilj ovog rada bio je odrediti osobitosti RSV i hMPV infekcija donjih dišnih puteva u hospitalizirane djece u razdoblju od 01. siječnja 2010. do 31. prosinca 2014. godine. U navedenom razdoblju hospitalizirano je ukupno 726 djece s akutnom infekcijom donjeg dišnog sustava u dobi do 5 godina života. RSV i hMPV su u kliničkim uzorcima dokazivani metodom izravne imunofluorescencije. RSV ili hMPV su dokazani u 476 od 726 bolesnika. Od toga je RSV bio uzročnik u 429 (90,13%), a hMPV u 47 (9,87%) slučajeva. Medijan dobi u RSV skupini bio je 3 mjeseca, a u hMPV skupini 6 mjeseci. U 6% bolesnika s RSV-om i 4,2% s hMPV-om bio je prisutan prematuritet ili srčana greška kao rizični čimbenik za težu bolest. Bakterijsku koinfekciju dišnog sustava imalo je 3,5% bolesnika u RSV skupini te 4,2% u hMPV skupini. Mehanički je bilo ventilirano 4,2% RSV pozitivne i 6,4% hMPV pozitivne djece. Gledajući ukupno cijelo razdoblje, hospitalizacije su bile najučestalije u zimskim mjesecima. Vrhunci RSV epidemija javljali su se u zimskim ili proljetnim mjesecima te su pratile bianualni uzorak pojavljivanja. HMPV se također javljao bianualno izmjenjujući se s RSV-om.

Abstract (english)

Respiratory syncytial virus and human metapneumovirus are important causes of acute lower respiratory tract infections in infants and young children. RSV primary infection most commonly occurs in infants aged 2 to 8 months, while hMPV is most common between 6 and 30 months of age. Outbreaks of RSV occur in biennial cycles, as a larger epidemic in winter followed by a smaller epidemic in spring of the next year. HMPV generally follows this pattern of occurrence. The aim of this study was to determine the characteristics of RSV and hMPV lower respiratory tract infections in hospitalized children in period from January 1st 2010 to December 31st 2014. In this period, a total of 726 children under 5 years of age with acute lower respiratory tract infection were hospitalised. Direct immunofluorescence assay (DFA) was used to detect the viruses in clinical samples. RSV and hMPV were detected in 476 out of 726 patients. RSV was causative agent in 429 (90.13%), and hMPV in 47 (9.87%) cases. The median age of RSV patients was 3 months, and hMPV patients 6 months. Prematurity or congenital heart defect as a risk factor for severe disease were present in 6% of patients with RSV and in 4.2% with hMPV infection. Bacterial coinfection was detected in 3.5% of patients in the RSV group and in 4.2% of the hMPV group. Mechanical ventilation was required in 4.2% RSV positive and 6.4% hMPV positive children. Hospitalizations were most common in the winter months. RSV epidemics peaked in winter and spring months and followed biennial pattern of occurrence. HMPV outbreaks also showed biennial pattern and were annualy alternating with RSV peaks.

• Keywords: respiratorni sincicijski virus; humani metapneumovirus; akutne infekcije donjeg dišnog sustava
• Keywords (english): respiratory syncytial virus; human metapneumovirus; lower respiratory tract infection
• Language: croatian
• URN:NBN: urn:nbn:hr:105:188191
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-07-14 08:44:24