Analysis of body composition performed by bioimpedance in obese patients with hypertension

master's thesis

• Title (croatian): Analiza sastava tijela bioimpedancijom u pretilih bolesnika s hipertenzijom
• Author: Darjan Ranilović
• Mentor: Maja Baretić (mentor)
• Committee member: Maja Baretić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Živka Dika (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Introduction: Prevalence of obesity and hypertension is increasing worldwide. Obesity and hypertension share many pathophysiological links and cardiovascular outcomes. -----
Aim: The aim of this thesis is to establish the difference in body composition between obese people with and without hypertension Patients and methods Data of 40 obese patients (body mass index – BMI >30 kg/ m2) were obtained retrospectively from Department of Endocrinology and Diabetology, Internal Medicine Clinic, University Hospital Centre Zagreb. Patients were divided in two groups; with hypertension (Group 1, 7 men and 13 women) and without hypertension (Group 2, 5 men and 15 women). Secondary causes of obesity were excluded. Control group were healthy non-obese normotensive individuals (Group 3, 6 men and 8 women). Body composition was estimated by bioelectrical impedance analysis (fat percentage, fat mass, muscle mass and visceral fat rating). -----
Results: Comparison of non-obese participants form Group 3 with obese ones from Group 1 and 2 showed that all of parameters of body composition estimated by bioelectrical impedance differ significantly. There was a positive correlation between BMI and fat mass in Group 1 and Group 2 (r=0.91 and r=0.80 respectively), but obese patients with hypertension had significantly more fat mass (p=0.01) and fat percentage (p= 0.02) than those without hypertension. Male obese hypertensive patients had more fat mass was found in than females. -----
Conclusion: Obese patients with and without hypertension have different body composition than non-obese normotensive individuals. Obese patients with hypertension have significantly more fat mass which is more prominent in males. Those finding confirm the fact that fat tissue produces bioactive molecules that promote development of obesity-associated hypertension.

Abstract (croatian)

Uvod: Prevalencija pretilosti i hipertenzije je sve veća. Pretilost i hipertenzija dijele mnoge
patofiziološke poveznice i imaju iste posljedice srčanožilnih bolesti. -----
Cilj: Cilj je utvrditi razliku sastava tijela između pretilih osoba s hipertenzijom i bez nje.
----- Ispitanici i metode: Retrospektivno su analizirani podaci 40 pretilih bolesnika (indeks tjelesne mase - ITM>30 kg/m2) praćenih na Zavodu za endokrinologiju i dijabetologiju, Klinike interne medicine, Kliničkog bolničkog centra Zagreb. Bolesnici su podijeljeni u dvije skupine;
na one s hipertenzijom (Grupa 1, 7 muškaraca i 13 žena) i bez hipertenzije (Grupa 2, 5 muškaraca i 15 žena). Sekundarni uzroci pretilosti su isključeni. Kontrolnu skupinu činili su normotenzivni ispitanici uredne tjelesne mase (Grupa 3, 6 muškaraca i 8 žena). Sastav tijela procijenjen je bioelektričnom impedancijom (udio masti, masa masti, masa mišića i visceralna
masnoća). -----
Rezultati: Usporedba ispitanika normalne tjelesne mase iz Grupe 3 s pretilima iz Grupe 1 i 2 pokazala je da se svi parametri sastava tijela procijenjeni bioelektričnom impedancijom statistički značajno razlikuju. Nađena je pozitivna korelacija između ITM-a i mase masti u Grupi 1 i Grupi 2 (r = 0,91 i r = 0,80), no pretili bolesnici s hipertenzijom imali su značajno višu masu tjelesne masti (p = 0,01) i udio masti (p = 0,02) od onih bez hipertenzije. U muških
pretilih bolesnika s hipertenzijom bilo je više tjelesnih masti nego kod žena. -----
Zaključak: Pretili bolesnici s i bez hipertenzije imaju drugačiji tjelesni sastav od normotenzivnih osoba koje nisu pretile. Pretili bolesnici s hipertenzijom imaju znatno veću masu tjelesne masti koja je izraženija kod muškaraca. Ti nalazi potvrđuju činjenicu da masno tkivo proizvodi bioaktivne molekule koje potiču razvoj hipertenzije povezane s pretilošću.

• Keywords: body composition; bioimpedance; obesity; hypertension
• Keywords (croatian): kompozicija tijela; bioimpedancija; pretilost; hipertenzija
• Language: english
• URN:NBN: urn:nbn:hr:105:556465
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-07-22 09:38:24