Clinical and radiological characteristics of functional adrenal tumors

master's thesis

• Title (croatian): Kliničke i radiološke karakteristike funkcionalnih tumora nadbubrežne žlijezde
• Author: Yamit Miriam Berl
• Mentor: Tina Dušek (mentor)
• Committee member: Tina Dušek (predsjednik povjerenstva)
• Committee member: Darko Kaštelan (član povjerenstva)
• Committee member: Nikola Đaković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2019-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

OBJECTIVE: To perform statistical analysis of the radiological findings of adrenal gland tumors found in patients referred to the department of endocrinology in the University Hospital Center Zagreb between the years of 2011-2016. With the aim of improving the diagnosis process, such patients need to go through. ----- METHODS: The patients utilized in this study accounted for the KBC Zagreb patient registry. The data was then analyzed via an Excel database and manifested into a conclusion. Literature used in this study was found using Medline via the MeSH search engine using the same keywords listed below. ----- RESULTS: Data on tumors include adenomas, PHEO and ACC. In our study the size of adrenal tumors classified as an adenoma on radiological testing ranged from 0.9 to 7.4 cm with an average of 3.95 cm; conversely, the diameter of ACCs ranged from 1.2 to 17.4 cm with an average of 10.1 cm. Additionally, in the results of our study 96% of PHD proven PHEO had non-adenoma radiological characteristics and the average size of these tumors was 6.3 cm. More so, among tumors that were larger than 4 cm and with radiological characteristics of a non-adenoma tumor, the prevalence of malignant tumors was 61 percent and of benign tumors was 38%. ----- CONCLUSION: Our study thus supports the hypothesis that tumor size and attenuation value greater than 10 HU on CT is correlated with malignancy potential of adrenal gland tumor. Furthermore, in order to optimize the accuracy of diagnostic testing for the work-up of adrenal gland masses, PHD should remain the preferred method.

Abstract (croatian)

CILJ: Za statističku analizu radioloških nalaza tumora nadbubrežne žlijezde pronađenih kod pacijenata upućenih na Zavod za endokrinologiju KBC-a Zagreb u razdoblju od 2011. do 2016. godine. U cilju poboljšanja dijagnostičkog procesa kroz kojeg takvi pacijenti moraju proći. ----- METODE: Podaci o pacijentima korišteni u ovoj studiji su preuzeti iz registra pacijenata KBC Zagreb te su analizirani putem Excelove baze podataka i prikazani u zaključku. Literatura korištena u ovom istraživanju pronađena je na Medline-u putem MeSH tražilice korištenjem istih ključnih riječi navedenih u nastavku. ----- REZULTATI: Podaci o tumorima uključuju adenome, feokromocitome i adrenokortikalne karcinome. U našem istraživanju veličina tumora nadbubrežne žlijezde klasificiranih kao adenom na radiološkom ispitivanju kretala se od 0,9 do 7,4 cm s prosjekom od 3,95 cm. Suprotno tom, promjer adrenokortikalnih karcinoma kretao se u rasponu od 1,2 do 17,4 cm s prosjekom od 10,1 cm. Osim toga, u rezultatima našeg istraživanja 96% PHD dokazanih feokromocitoma imalo je radiološke karakteristike neadenomskih tumora, a prosječna veličina tih tumora bila je 6,3 cm. Štoviše, među tumorima većim od 4 cm i s neadenomskim radiološkim karakteristikama, učestalost malignih tumora bila je 61%, a benignih tumora 38%. ----- ZAKLJUČAK: Naša studija stoga podupire hipotezu da je veličina tumora i vrijednost prigušenja veća od 10 HU na CT-u u korelaciji s malignim potencijalom tumora nadbubrežne žlijezde. Nadalje, kako bi se optimizirala točnost dijagnostičkih ispitivanja za obradu nadbubrežnih masa, PHD bi trebala ostati preferencijalna metoda.

• Keywords: adenoma; non-adenoma; Cushing syndrome; autonomous cortisol secretion; pheochromocytoma; hyperandrogenism; primary aldosteronism
• Keywords (croatian): adenom; neadenom; Cushingov sindrom; autonomno izlučivanje kortizola; feokromocitom; hiperandrogenizam; primarni aldosteronizam
• Language: english
• URN:NBN: urn:nbn:hr:105:501133
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-07-23 09:02:08