The association between clinical and laboratory findings of bullous pemphigoid and dipeptidyl peptidase-4 inhibitors in the elderly: a retrospective study

Scientific paper - Original scientific paper

• Author: Zrinka Bukvić Mokos; MBZ: 279423
• Author: Mikela Petković
• Author: Anamaria Balić
• Author: Branka Marinović
• Author's institution: University of Zagreb; School of Medicine; (Department of Dermatology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract (english)

Aim: To evaluate the association between the use of dipeptidyl peptidase-4 inhibitors (DPP4I) and clinical and laboratory findings of bullous pemphigoid (BP) in patients treated at the European Reference Network - Skin Reference Centre in Croatia. ----- Methods: This retrospective study enrolled 82 patients treated for BP at the Department of Dermatovenereology, University Hospital Center Zagreb from January 2015 to December 2019. Clinical features of BP, presence of comorbidities, and laboratory findings of anti-BP antibodies and eosinophilia were analyzed in three groups of BP patients: 1) diabetes mellitus (DM) type II patients treated with DPP4I, 2) DM type II patients not treated with DPP4I, and 3) non-DM type II patients. ----- Results: The average age and anti-BP180 titer were similar in all three groups. DPP4I group had a slightly lower eosinophil level in both peripheral blood (4.89%) and biopsy specimens (87.5%), but the difference was not significant. The prevalence of inflammatory BP in DPP4I group was 76.5%. DPP4I group had significantly higher percentage of patients with chronic renal failure and dementia (52.9% and 11.8%, respectively) compared with non-DPP4I DM (14.3% and 0%, respectively) and non-DM type II patients (15.7% and 0%, respectively). ----- Conclusion: BP patients treated with DPP4I and those not treated with DPP4Is did not significantly differ in laboratory findings. However, DPP4I treatment was associated with an inflammatory subtype of BP and a higher prevalence of dementia and chronic renal failure. These findings warrant further research into the association of BP and DM with dementia and chronic renal failure.

• Keywords (english): Croatia; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / drug therapy; Dipeptidyl-Peptidase IV Inhibitors / adverse effects; Dipeptidyl-Peptidase IV Inhibitors / therapeutic use; Eosinophils; Humans; Pemphigoid, Bullous / chemically induced; Pemphigoid, Bullous / epidemiology; Retrospective Studies
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 61, no. 2, pp. 93-99
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2020.61.93
• URN:NBN: urn:nbn:hr:105:598782
• Publication: 2020-04-30
• Document URL: http://www.cmj.hr/2020/61/2/32378375.htm
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-10-27 12:49:01