Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

Scientific paper - Review paper

• Author: Tomo Svaguša
• Author: Mislav Martinić
• Author: Matea Martinić
• Author: Lucija Kovačević
• Author: Ana Šepac
• Author: Davor Miličić
• Author: Joško Bulum
• Author: Boris Starčević
• Author: Maja Sirotković-Skerlev
• Author: Fran Seiwerth
• Author: Ana Kulić
• Author: Filip Sedlić
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Author's institution: University of Zagreb; School of Medicine; (Department of Pathology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathology

Abstract (english)

Mitochondria are involved in crucial homeostatic processes in the cell: the production of adenosine triphosphate and reactive oxygen species, and the release of pro-apoptotic molecules. Thus, cell survival depends on the maintenance of proper mitochondrial function by mitochondrial quality control. The most important mitochondrial quality control mechanisms are mitochondrial unfolded protein response, mitophagy, biogenesis, and fusion-fission dynamics. This review deals with mitochondrial quality control in heart diseases, especially myocardial infarction and heart failure. Some previous studies have demonstrated that the activation of mitochondrial quality control mechanisms may be beneficial for the heart, while others have shown that it may lead to heart damage. Our aim was to describe the mechanisms by which mitochondrial quality control contributes to heart protection or damage and to provide evidence that may resolve the seemingly contradictory results from the previous studies.

• Keywords (english): Aging / physiology; Heart Diseases / metabolism; Humans; Mitochondria / metabolism; Mitophagy / physiology; Unfolded Protein Response / physiology
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 61, no. 2, pp. 126-138
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2020.61.126
• URN:NBN: urn:nbn:hr:105:828961
• Publication: 2020-04-30
• Document URL: http://www.cmj.hr/2020/61/2/32378379.htm
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-11-05 17:02:41