Significance of Extra-Esophageal Symptoms in Pediatric Gastroesophageal Reflux Disease

Scientific paper - Original scientific paper

• Author: Andro Košec
• Author: Orjena Žaja
• Author: Filip Matovinović
• Author: Boris Jelavić
• Author: Tomislav Baudoin
• Author's institution: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract (english)

Introduction: Current practice guidelines in gastroesophageal reflux disease (GERD) often require invasive diagnostic testing. ----- Objective: The aim of the present study was to evaluate the significance of extra-esophageal symptoms and reliability of a screening risk score that is simple to use. ----- Methods: A longitudinal retrospective single-institution cohort study. Setting: A university clinical hospital tertiary referral center. The present study enrolled pediatric patients with symptoms suggestive of GERD: epigastric pain, occasional nausea, regurgitation, tasting acid in the oral cavity, chronic cough, hoarseness of voice, frequent throat clearing. The patients underwent 24-hour esophageal pH monitoring and fiber-optic laryngoscopy. The correlations between the local findings, anamnestic and objective measurement data were analyzed. ----- Results: The present study evaluated 89 pediatric patients. Patients with asthma presented significantly more often with adjoining gastrointestinal symptoms (p = 0.0472). Patients that were obese were linked to a higher rate of reports of gastrointestinal symptoms (p = 0.0495). After the patients had been assigned to newly developed risk groups, obesity showed to be significantly more frequent in patients placed in higher risk groups ( p < 0.0001) for a positive GERD diagnosis. ----- Conclusion: Patients with leading symptoms of asthma presented significantly more often with adjoining gastrointestinal symptoms. Obesity showed to be significantly more frequent in patients placed in higher risk groups for a positive GERD diagnosis.

• Keywords (english): diagnostics; obesity; pediatric gastroesophageal reflux disease; screening
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: International Archives of Otorhinolaryngology
• Numbering: vol. 24, no. 04, pp. e472-e476
• p-ISSN: 1809-9777
• e-ISSN: 1809-4864
• DOI: https://doi.org/10.1055/s-0039-3402437
• URN:NBN: urn:nbn:hr:105:298949
• Publication: 2020-08
• Document URL: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-3402437
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-01-18 09:56:05