Autonomic dysfunction in people with neuromyelitis optica spectrum disorders

Scientific paper - Original scientific paper

• Author: Luka Crnošija
• Author: Magdalena Krbot Skorić
• Author: Marko Andabaka
• Author: Anamari Junaković
• Author: Vanja Martinović
• Author: Jovana Ivanović
• Author: Šarlota Mesaroš
• Author: Tatjana Pekmezović
• Author: Jelena Drulović
• Author: Mario Habek
• Author's institution: University of Zagreb; School of Medicine; (Department of Neurology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Neurology

Abstract (english)

Aims: To determine the difference in autonomic symptom burden measured with the Composite Autonomic System Score-31 (COMPASS-31) and presence of objective dysautonomia in people with neuromyelitis optica spectrum disorders (pwNMOSD) compared to people with multiple sclerosis (pwMS). -----

Design/methods: Twenty pwNMOSD and 20 pwMS, matched for age, sex, and disease duration, were enrolled. All patients completed the COMPASS-31. The quantification of cardiovascular autonomic dysfunction (CAD) was made using the two indices of the Composite Autonomic Scoring Scale (CASS): adrenergic index (AI) and cardiovagal index (CI). -----

Results: In all pwNMOSD, COMPASS-31 was >0. Sympathetic dysfunction was present in 8 (40%), parasympathetic dysfunction in 10 (50%), and orthostatic hypotension in 6 (30%) pwNMOSD. This group of patients had higher frequency and level on the pupillomotor domain of the COMPASS-31 compared to pwMS (p = 0.048 and p = 0.006, respectively). A binary logistic regression model showed that drop in diastolic blood pressure (dBP) during tilt-table test and normal function of autonomic nervous system, defined as AI = 0 and CI = 0, were independent predictors of pwNMOSD (p = 0.042 and p = 0.029, respectively). If CAD was present, it was significantly worse in pwNMOSD compared to pwMS (p = 0.003). -----

Conclusion: Significant proportion of pwNMOSD experience dysautonomia, which seems to be different from dysautonomia observed in pwMS.

• Keywords (english): neuromyelitis optica spectrum disorders; autonomic dysfunction; multiple sclerosis
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Multiple Sclerosis Journal
• Numbering: vol. 26, no. 6, pp. 688-695
• p-ISSN: 1352-4585
• e-ISSN: 1477-0970
• DOI: https://doi.org/10.1177/1352458519837703
• URN:NBN: urn:nbn:hr:105:997279
• Publication: 2020-05
• Document URL: http://journals.sagepub.com/doi/10.1177/1352458519837703
• Type of resource: Text
• Access conditions: Open access; Embargo expiration date: 2021-05-31
• Created on: 2021-01-18 12:29:47