Importance of ovarian tissue cryopreservation in fertility preservation and anti-aging treatment

Professional paper - Review paper

• Author: Petra Vuković
• Author: Miro Kasum
• Author: Darko Orešković
• Author: Ermin Čehić
• Author: Jelena Raguž
• Author: Shkelzen Elezaj
• Author: Lidija Beketić-Orešković
• Author's institution: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract (english)

Various oncological and non-oncological diseases, as well as their treatments, can cause premature ovarian insufficiency and reduce a woman's reproductive potential. Fertility preservation is, therefore, becoming an emerging field of reproductive medicine allowing these patients to have their own biological children. The aim of this review is to analyze the importance of ovarian tissue cryopreservation as a fertility preservation method as well as its new role as a hormone replacement treatment. Although ovarian tissue cryopreservation is currently regarded as an experimental procedure, it is rapidly advancing and may become an established fertility preservation method in the near future. This method does not require ovarian stimulation or a subsequent delay in the initiation of cancer treatment. Furthermore, orthotopic ovarian tissue transplantation offers the unique opportunity of spontaneous conception. Due to the restoration of endocrine function following the procedure, ovarian tissue cryopreservation may also be used as tissue hormone replacement therapy in cases of premature ovarian insufficiency, to postpone menopause and prevent its troublesome symptoms and diseases. Even though the role of ovarian tissue cryopreservation as a new anti-aging treatment modality is quite promising, the safety and efficacy of this approach should be investigated in clinical settings.

• Keywords (english): Aging; Cryopreservation; Estrogen Replacement Therapy; Female; Fertility Preservation; Humans; Ovary / transplantation
• Language: english
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Gynecological Endocrinology
• Numbering: vol. 35, no. 11, pp. 919-923
• p-ISSN: 0951-3590
• e-ISSN: 1473-0766
• DOI: https://doi.org/10.1080/09513590.2019.1611763
• URN:NBN: urn:nbn:hr:105:029847
• Publication: 2019-11
• Document URL: https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1611763
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-11 10:12:14