prikaz prve stranice dokumenta Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT
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Scientific paper - Original scientific paper
Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT
Journal of Hematology & Oncology, 12 (2019), 1; 108. https://doi.org/10.1186/s13045-019-0790-x
Pavlů, Jiří; Labopin, Myriam; Niittyvuopio, Riitta; Socié, Gerard; Yakoub-Agha, Ibrahim; Wu, Depei; Remenyi, Peter; Passweg, Jakob; Beelen, Dietrich W.; Aljurf, Mahmoud; Kröger, Nicolaus; Labussière-Wallet, Hélène; Perić, Zinaida; Giebel, Sebastian; Nagler, Arnon; Mohty, Mohamad More authors...

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Pavlů, J., Labopin, M., Niittyvuopio, R., Socié, G., Yakoub Agha, I., Wu, D. ... Mohty, M. (2019). Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT. Journal of Hematology & Oncology, 12. (1). doi: 10.1186/s13045-019-0790-x

Pavlů, Jiří, et al. "Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT." Journal of Hematology & Oncology, vol. 12, no. 1, 2019. https://doi.org/10.1186/s13045-019-0790-x

Pavlů, Jiří, Myriam Labopin, Riitta Niittyvuopio, Gerard Socié, Ibrahim Yakoub Agha, Depei Wu, Peter Remenyi, et al. "Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT." Journal of Hematology & Oncology 12, no. 1 (2019). https://doi.org/10.1186/s13045-019-0790-x

Pavlů, J., et al. (2019) 'Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT', Journal of Hematology & Oncology, 12(1). doi: 10.1186/s13045-019-0790-x

Pavlů J, Labopin M, Niittyvuopio R, Socié G, Yakoub Agha I, Wu D, and sur.. Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT. Journal of Hematology & Oncology [Internet]. 2019 October 23 [cited 2024 April 12];12(1). doi: 10.1186/s13045-019-0790-x

J. Pavlů, et al., "Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT", Journal of Hematology & Oncology, vol. 12, no. 1, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:030394. [Accessed: 12 April 2024]

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Title (english)Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT
AuthorJiří Pavlů
AuthorMyriam Labopin
AuthorRiitta Niittyvuopio
AuthorGerard Socié
AuthorIbrahim Yakoub-Agha
AuthorDepei Wu
AuthorPeter Remenyi
AuthorJakob Passweg
AuthorDietrich W. Beelen
AuthorMahmoud Aljurf
AuthorNicolaus Kröger
AuthorHélène Labussière-Wallet
AuthorZinaida Perić
AuthorSebastian Giebel
AuthorArnon Nagler
AuthorMohamad Mohty
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: Assessment of measurable residual disease (MRD) is rapidly transforming the therapeutic and prognostic landscape of a wide range of hematological malignancies. Its prognostic value in acute lymphoblastic leukemia (ALL) has been established and MRD measured at the end of induction is increasingly used to guide further therapy. Although MRD detectable immediately before allogeneic hematopoietic cell transplantation (HCT) is known to be associated with poor outcomes, it is unclear if or to what extent this differs with different types of conditioning. ----- Methods: In this retrospective registry study, we explored whether measurable residual disease (MRD) before allogeneic hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia is associated with different outcomes in recipients of myeloablative total body irradiation (TBI)-based versus chemotherapy-based conditioning. We analyzed outcomes of 2780 patients (median age 38 years, range 18-72) who underwent first HCT in complete remission between 2000 and 2017 using sibling or unrelated donors. ----- Results: In 1816 of patients, no disease was detectable, and in 964 patients, MRD was positive. Conditioning was TBI-based in 2122 (76%) transplants. In the whole cohort MRD positivity was a significant independent factor for lower overall survival (OS) and leukemia-free survival (LFS), and for higher relapse incidence (RI), with respective hazard ratios (HR, 95% confidence intervals) of 1.19 (1.02-1.39), 1.26 (1.1-1.44), and 1.51 (1.26-1.8). TBI was associated with a higher OS, LFS, and lower RI with HR of 0.75 (0.62-0.90), 0.70 (0.60-0.82), and 0.60 (0.49-0.74), respectively. No significant interaction was found between MRD status and conditioning. When investigating the impact of MRD separately in the TBI and chemotherapy-based conditioning cohorts by multivariate analysis, we found MRD positivity to be associated with lower OS and LFS and higher RI in the TBI group, and with higher RI in the chemotherapy group. TBI-based conditioning was associated with improved outcomes in both MRD-negative and MRD-positive patients. ----- Conclusions: In this large study, we confirmed that patients who are MRD-negative prior to HCT achieve superior outcomes. This is particularly apparent if TBI conditioning is used. All patients with ALL irrespective of MRD status benefit from TBI-based conditioning in the myeloablative setting.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Hematology & Oncology
Numberingvol. 12, no. 1, 108
e-ISSN1756-8722
DOIhttps://doi.org/10.1186/s13045-019-0790-x
URN:NBNurn:nbn:hr:105:030394
Publication2019-10-23
Document URLhttps://jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0790-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-02-23 09:54:58