Modaliteti kirurškog liječenja planocelularnog karcinoma usne šupljine

master's thesis

• Title (english): Modalities of surgical treatment of oral cavity squamous cell carcinoma
• Author: Josip Antić
• Mentor: Ivica Lukšić (mentor)
• Committee member: Martin Jurlina (predsjednik povjerenstva)
• Committee member: ŽELJKO ORIHOVAC (član povjerenstva)
• Committee member: Ivica Lukšić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Maxillofacial Surgery and Dentistry); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Prosječna svjetska godišnja incidencija karcinoma usne šupljine iznosi 4/100.000, a smrtnost 1,9/100.000 uzrokujući smrt preko 170.000 ljudi širom svijeta svake godine. Planocelularni karcinom čini barem 90% svih malignih neoplazmi usne šupljine. Pušenje i alkohol najvažniji su etiološki čimbenici uz upitan status HPV u nastanku karcinoma usne šupljine. Prekancerozne lezije poput leukoplakije i eritroplakije često prethode nastanku karcinoma. Klinička je slika najčešće nespecifična i pacijenti se žale na ranu koja ne zacjeljuje. Anamneza i fizikalni pregled ključni su u postavljanju dijagnoze, a biopsija lezije zlatni standard u potvrdi dijagnoze. Slikovne pretrage slijede u pripremi za operaciju i u svrhu stupnjevanja karcinoma. Terapijske mogućnosti jesu radioterapija, kemoterapija, biološka terapija i najčešća kirurška terapija. Ovisno o raširenosti bolesti kirurški modaliteti jesu intraoralna ekscizija i složena operacija ekscizije tumora u bloku s disekcijom vrata. Kirurgija spašavanja primjenjuje se nakon neuspjeha prve terapijske opcije. Komplikacije kirurških operacija teške su i uključuju: krvarenje, infekcije, dehiscenciju rane, neurološke komplikacije zbog oštećenja kranijalnih živaca, smetnje govora, gutanja i estetsku disfiguraciju. Rekonstrukcija se danas radi kod svake operacije u kojoj nije moguće primarno zatvaranje rane. Ovaj diplomski rad obuhvaća pregled osnovnih epidemioloških, etioloških, kliničkih i dijagnostičkih podataka o bolesti s posebnim osvrtom na modalitete kirurškog liječenja,
prednosti, mane i komplikacije istih.

Abstract (english)

The global average annual incidence of oral cancer is 4/100,000 and the mortality is 1.9/100,000 causing the deaths of over 170,000 people worldwide each year. Squamous cell carcinoma accounts for at least 90% of all malignant neoplasms of the oral cavity. Smoking and alcohol are the most important etiological factors with the status of HPV being questionable in the development of oral cancer. Precancerous lesions such as leukoplakia and erythroplakia often precede the development of cancer. The clinical presentation is most often nonspecific and patients usually complain of a wound that does not heal. Patient’s history and physical examination are crucial in diagnosing the illness and biopsy of the lesion is the gold standard in confirming the diagnosis. Diagnostic imaging is used in preparation for surgery and for the purpose of staging. Therapeutic options are radiotherapy, chemotherapy, biological therapy and the most common one – surgical therapy. Depending on the spread of the disease, surgical modalities are intraoral excision and composite tumor excision surgery in block with neck dissection. Salvage surgery is applied after the failure of the first therapeutic option. Complications of surgical operations are severe and include: bleeding, infections, wound dissociation, neurological complications due to cranial nerve damage, speech disorders, difficulty swallowing and aesthetic disfigurement. Today
reconstruction is performed in every operation in which primary closure of the wound is not possible. This thesis includes a review of basic epidemiological, etiological, clinical and diagnostic data on the disease with special reference to the modalities of surgical treatment, its advantages, disadvantages and complications.

• Keywords: planocelularni karcinom; usna šupljina; kirurško liječenje; intraoralna ekscizija; blok resekcija
• Keywords (english): squamous cell carcinoma; oral cavity; surgical treatment; intraoral excision; en bloc resection
• Language: croatian
• URN:NBN: urn:nbn:hr:105:855509
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-03 09:59:17